Synthesis of Zingerone Using NiCl2•6H2O-NaBH4 as a Selective Hydrogenation Reaction Agent

Murdiah Murdiah; Deni Pranowo; Tri Joko Raharjo

doi:10.4028/www.scientific.net/MSF.948.127

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HomeMaterials Science ForumMaterials Science Forum Vol. 948Synthesis of Zingerone Using NiCl2•6H2O-NaBH4 as a...

Synthesis of Zingerone Using NiCl₂•6H₂O-NaBH₄as a Selective Hydrogenation Reaction Agent

Abstract:

Synthesis of zingerone (4-(4-hydroxy-3-methoxyphenyl)-2-butanone) has been done. The first step was to synthesize the compound (4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-on) through a cross aldol condensation reaction between vanilin:acetone mol ratio of 1:5:5, for 5 hours in high yields (97%). The second step was the selective hydrogenation of (4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-on) with NiCl₂•6H₂O-NaBH₄ catalyst in mild condition. Based on the FT-IR, ¹³C-NMR and ¹H-NMR and GC-MS analyses, the synthesis of zingerone has been successfully synthesized by selective hydrogenation reaction with 80% yield.

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Materials Science Forum (Volume 948)

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127-132

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https://doi.org/10.4028/www.scientific.net/MSF.948.127

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March 2019

Authors:

Murdiah Murdiah, Deni Pranowo*, Tri Joko Raharjo

Keywords:

Selective Hydrogenation, Synthesis, Zingerone

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