Chemical Synthesis of Monosaccharide Lauric Acid Esters as Antibacterial and Antifungal Agents

Abstract:

Synthesis of glucose laurate (GLC12), fructose laurate (FRU12), and galactose laurate (GAL12) as antibacterial and antifungal agents has been carried out. The synthesis of GLC12, FRU12, and GAL12was conducted by reacting lauroyl chloride with glucose, fructose, and galactose in the presence of pyridine in 36.1; 77.8; and 72,2% yields respectively for GLC12, FRU12 and GAL12.Antibacterial and antifungal activity test was done using well diffusion method towards Gram-negative bacteria (Salmonella thypimurium and Escherechia coli), Gram-positive bacteria (Staphylococcus aureus and Bacillussubtilis), Candida albicans fungus, DMSO as a negative control, and 4-isopropyl-3-methylphenol 1% as a positive control. The best antibacterial activity was shown by FRU12at 12.5% of concentration against S.aureusand B.subtilis bacteria.

• Periodical: Materials Science Forum (Volume 948)
• Pages: 63-68
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.948.63
• Online since: March 2019
• Authors: Mutmainah Mutmainah, Jumina Jumina*, Bambang Purwono
• Keywords: Antibacterial, Antifungal, Carbohydrate Esters, Lauric Acid

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