Medical Applications of Biomaterials: The Case of Design and Manufacture of Orthopedic Corsets Made of Polylactic Acid by Additive Manufacturing

Abstract:

At present, biomaterials are used in several sectors of medicine such as implant manufacturing, tissue engineering, orthopedic and prosthetic aids, drug delivery systems and many others. The use of biomaterials is increasingly related to the additive manufacturing (AM) of various medical devices and aids. Biomaterials and their use in medicine are important not only in terms of their biocompatibility and direct effect on the human organism, but also in terms of their biodegradability, processability and non-toxicity to the environment either during their production or during their processing after use. Bioplastics of the type Polylactic acid (PLA) appears to be a suitable biomaterials for use in a variety of medical applications in conjunction with an AM process. For this reason, this article discusses 1) description and use of biomaterials in medical applications 2) AM and biomaterials 3) key properties and uses of PLA bioplastics in medicine and 4) the specific AM of an orthopedic corset made of PLA and its benefits.

• Periodical: Materials Science Forum (Volume 952)
• Pages: 223-232
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.952.223
• Online since: April 2019
• Authors: Ivan Molnár*, Ladislav Morovič, Daynier Rolando Delgado Sobrino, Šimon Lecký, Dávid Michal
• Keywords: Additive Manufacturing, Biocompatibility, Biodegradability, Biomaterial, Bioplastic, Polylactic Acid

References

[1] Ch. A. Harper, Modern plastics handbook. Technology Seminars, Inc., Lutherville, Maryland, (1999).

[2] E. J. North, R. U. Halden, Plastics and Environmental Health: The Road Ahead. Rev Environ Health (2013). Information on https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791860.

[3] D. Mihov, B. Katerska, Some Biocompatible Materials Used in Medical Practice. Trakia Journal of Sciences, Vol. 8, Suppl. 2, (2010) pp.119-125. Information on https://pdfs.semanticscholar.org/b083/a7c4a7e4de6ffc4525e1d13a0839f322db80.pdf.

[4] C.P. Bergmann, A. Stumpf, Dental Ceramics: Microstructure, Properties and Degradation (2013), VII, 84 p. ISBN: 978-3-642-38223-9.

[5] R. Păcurar, A. Păcurar, Applications of the Selective Laser Melting Technology in the Industrial and Medical Fields, in: I.V. Shishkovsky (Ed.), New Trends in 3D Printing, IN-Tech, Rijeka, (2016).

[6] C. Cosma, N. Bâlc, M. Moldovan, L. Morovič, P. Gogola, C. Miron Borzan, Post-processing of customized implants made by laser beam melting from pure Titanium, J. Optoelectron. Adv. M. 11-12 (2017) 738-747.

[7] C.Ş. Borzan, P. Berce, H. Chezan, E. Sabău, S.A. Radu, M. Ridzoň, Physico-Mechanical Properties Characterization of the Parts from PA 2200 Manufactured by Selective Laser Sintering Technology, Academic Journal of Manufacturing Engineering. 11 (2013) 108-113.

[8] H. N. Chia, B. M. Wu, Recent advances in 3D printing of biomaterials, Journal of Biological Engineering (2015) 9:4. Information on https://www.ncbi.nlm.nih.gov.

[9] I. Molnár, Research of design and manufacture of orthopedic appliance by 3D digitizing and Rapid Prototyping. [Written project for dissertation examination]-Slovak University of Technology in Bratislava. Faculty of Materials Science and Technology in Trnava. Institute of Production Technologies – Supervisor: doc. Ing. Ladislav Morovič, PhD. – Trnava: MTF STU, (2018) 73 p.

DOI: 10.17973/mmsj.2021_12_2021128

[10] R. P. Pawar, S. U. Tekale, S. U. Shisodia, J. T. Totre, A. J. Domb, Biomedical Applications of Poly(Lactic Acid). Recent Patents on Regenerative Medicine (2014) 4, pp.40-51. Information on https://www.researchgate.net.

DOI: 10.2174/2210296504666140402235024

[11] K. Hamad, M. Kaseem, H. W. Yang, F. Deri, Y. G. Ko, Properties and medical applications of polylactic acid: a review. eXPRESS Polymer Letters Vol.9, No.5 (2015) p.435–455. Information on https://www.expresspolymlett.com.

DOI: 10.3144/expresspolymlett.2015.42

[12] Prints of Polylactic acid (PLA, polylactide) bioplastic, chemical structure. Compostable polymer used in medical implants, 3D printing, packaging materials, etc., Fotosearch. Information on https://www.fotosearch.com/impresion/CSP996/k17261426.

[13] R. Rebelo, M. Fernandes, R. Fangueiro, Biopolymers in Medical Implants: A Brief Review. Procedia Engineering (2017) p.236–243. Information on https://www.sciencedirect.com.

DOI: 10.1016/j.proeng.2017.07.034

[14] Royal Screw, Royal Medical. Information on http://royalmedicalltd.com/royal-screw.

[15] R. A. A. Alsaheb, A. Aladdin, N. Z. Othman, R. A. Maleki, O. M. Leng, R. Aziz, H. A. El Enhasy, Recent application of polylactic acid in pharmaceutical and medical industries. Journal of Chemical and Pharmaceutical Research, 2015, 7(12):51-63. Information on https://www.jocpr.com.

[16] Stretch blowmolding modifies bioresorbable stent properties, Design News (2012). Information on https://www.designnews.com/content/stretch-blowmolding-modifies-bioresorbable-stent- properties/37936242517379.

[17] M. A. Cuiffo, J. Snyder, A. M. Elliott, N. Romerro, S. Kannan, G. P. Halada, Impact of the Fused Deposition (FDM) Printing Process on Polylactic Acid (PLA) Chemistry and Structure. Appl. Sci. (2017).

DOI: 10.20944/preprints201704.0010.v1

[18] L. Morovič, Non-Contact Measurement of Free-Form Surfaces, Aleš Čeněk, Plzeň, (2016).

[19] J. Vagovský, I. Buranský, A. Görög, Evaluation of measuring capability of the optical 3D scanner, Procedia Engineering. 100 (2015) 1198-1206.

DOI: 10.1016/j.proeng.2015.01.484