Formulation Development and In Vitro Evaluation of Buccal Tablets of Ramipril

D.Nagasamy Venkatesh; Raman Rajeshkumar; Roan Ngoc Anh Huy

doi:10.4028/www.scientific.net/MSF.987.83

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HomeMaterials Science ForumMaterials Science Forum Vol. 987Formulation Development and In Vitro Evaluation of...

Formulation Development and In Vitro Evaluation of Buccal Tablets of Ramipril

Abstract:

The main objective of the present investigation was to develop buccal tablets of ramipril, to bypass the first pass metabolism and to improve its oral bioavailability. Ramipril, an ACE inhibitor used in the treatment of hypertension undergoes extensive first pass metabolism and about 25% of the drug reaches the systemic circulation. A unidirectional, bilayered mucoadhesive tablet of ramipril was prepared using HPMC as polymer by direct compression technique. Initially, a backing layer was made by using ethyl cellulose, onto which the drug containing layer as placed and recompressed to get a bilayered tablet. The buccal tablets were evaluated for various parameters such as weight variation test, thickness, hardness, friability, in vitro swelling studies, in vitro mucoadhesion study and in vitro dissolution study. Among the different formulation, the formulation (F1) prepared using 5% HPMC as polymer exhibited satisfactory performance over the other batches and considered as an ideal batch. The release of the drug from the tablets exhibited zero order kinetics and the mechanism of release was governed by diffusion process.

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International Symposium on Advanced Material Research III

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Periodical:

Materials Science Forum (Volume 987)

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83-87

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https://doi.org/10.4028/www.scientific.net/MSF.987.83

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Online since:

April 2020

Authors:

D.Nagasamy Venkatesh*, Raman Rajeshkumar, Roan Ngoc Anh Huy

Keywords:

Buccal Tablets, In Vitro Release Studies, Ramipril, Release Kinetics

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References

[1] .K.Jain, Controlled and novel drug delivery, I Edn, CBS Publishers, New Delhi. (2002).

Google Scholar

[2] H. Amir Shojaei, Buccal mucosa as a route for systemic drug delivery – A review, J Pharm Pharmceut Sci, 1(1), 1998, 15-30.

Google Scholar

[3] B.Rajesh, A.Gandhi, R.Joseph, B.Robinson, Oral cavity as a site for bioadhewive durg delivery, Adv Drug Deliv Rev, 13 (1993), 43-47.

Google Scholar

[4] R.C. Hanne, K Andersen, K.Simonsen A.Lindekaer, J.Bonde, R.A. Helle, P.K. Jens. Pharmacology & Toxicology, 86(4): (2008), 178-82.

Google Scholar

[5] The Indian Pharmacopoeia; Vol 2, (2007). p.1034.

Google Scholar

[6] T. Higuchi. Mechanism of sustained action medication: Theoretical analysis of rate of solid drugs dispersed in solid matrices. J Pharm Sci. 52(12), (1963), 1145-49.

DOI: 10.1002/jps.2600521210

Google Scholar