Paper Titles

The Viability of Organic Dyes in Luminescent Down-Shifting Layers for the Enhancement of Si Solar Cell Efficiency
p.71

Development of a Bioanod, Experimental Studies and Mathematical Modelling of Membraneless Microbial Fuel Cell
p.77

Supercapacitors with Extended Operating Potential Window
p.84

Surface Morphology Studies on Laser Irradiated Target and Bi(Pb)SrCaCuO Thin Films
p.89

Efficiency Improvement of Gelatin-Based Wound Dressings by Silk Fibroin and Chitosan
p.97

Effect of Polylactic Acid/Hydroxyapatite Coating on Dental Implant Using Finite Element Method
p.103

Protein Nanoparticles with Enzymatic and Antigen-Binding Activities Induce Th1 Cytokine Gene Expression
p.109

Investigation on Effect of Varying Weight Percentage of Glass Fiber and Filler on the Properties of Glass Fiber-Cement- Polyester Composites
p.117

Numerical Investigation on the CFRP Strengthened Steel Frame under Earthquake
p.123

HomeMaterials Science ForumMaterials Science Forum Vol. 995Efficiency Improvement of Gelatin-Based Wound...

Efficiency Improvement of Gelatin-Based Wound Dressings by Silk Fibroin and Chitosan

Article Preview

Abstract:

Wound healing is a natural process of human body. When the wound size exceeds the critical point for naturally body healing, the fibrous tissue will play their parts and created a scar. Therefore, extra treatment has been added to eliminate the body limitations. Currently, there are a lot of commercial bioactive wound healing and dressing due to its physiological and biological abilities. In wound healing process, high moisture condition is also required. In order to accelerate the wound healing process, Tissue engineering (TE) is recommended. The increasing of cell proliferation by TE will be increased the chance for wound healing acceleration. In this study, the combination of Gelatin (Gel), Chitosan (CS) and Silk Fibroin (SF) were varied mixed in 10 ratios and fabricated the structure by lyophilisation technique. The elastic ability, biodegradability, structure and pore morphology, porosity, swelling ability, and biotoxicity were observed in each ratio. Gel provided highest elastic ability and biodegradability. The addition of SF and CS in Gel decreased biodegradation rate and activate fibroblast cell proliferation. Therefore, CS and SF could increase efficiency of gelatin-base wound dressings for a variety of utilization.

You might also be interested in these eBooks

Frontiers of Composite Materials IV

Info:

Periodical:

Materials Science Forum (Volume 995)

Pages:

97-102

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.995.97

Citation:

Cite this paper

Online since:

June 2020

Authors:

Wassanai Wattanutchariya*, Kittiya Thunsiri, Suwichchaya Puntawang

Keywords:

Biodegradable, Biotoxicity, Chitosan, Gelatin, Silk Fibroin, Wound Dressing

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2020 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

* - Corresponding Author

[1] C.M. Murphy, F.J. O'Brien, D.G. Little, A. Schindeler: Eur Cell Mater Vol. 26 (2013), p.120.

[2] J.S. Boateng, K.H. Matthews, H.N. Stevens, G.M. Eccleston: J Pharm Sci Vol. 97 (2008), p.2892.

[3] J.A.M. Ramshaw, J.A. Werkmeister, V. Glatteur: Biotechnol Rev Vol.13 (1995), p.336.

[4] C.J. Doillon, F.H. Silver: Biomaterials Vol.7 (1986), p.3.

[5] M. Ishihara, K. Nakanishi, K. Ono, M. Sato, M. Kikuchi, Y. Saito, H. Yura, T. Matsui, H. Hattori, M. Uenoyama, A. Kurita: Biomaterials Vol.23 (2002), p.833.

DOI: 10.1016/s0142-9612(01)00189-2

[6] S.H. Liu, R.S. Yang, R. Al-Shaikh, J.M. Lane: Clin Orthop Res Vol.318 (1995), p.265.

[7] K.P. Rao: J Biomater Sci Polym Ed Vol.7 (1995), p.623.

[8] M. Mian, F. Beghe, E. Mian: Int J Tissue React Vol.14 (1992), p.1.

[9] J. Ratanavaraporn, S. Damrongsakkul, N. Sanchavanakit, T. Banaprasert, S. Kanokpanont: J Met Mat Min Vol.16 (2006), p.31.

[10] H. Ueno, T. Mori, T. Fujinaga: Adv Drug Deliv Rev Vol.52 (2001), p.105.

[11] Y. Gutha, J.L. Pathak, W. Zhang, Y. Zhang, X. Jiao: Int J Biol Macromol Vol.10 (2017), p.234.

[12] W. Zhang, L. Chen, J. Chen, L. Wang, X. Gui, J. Ran, G. Xu, H. Zhao, M. Zeng, J. Ji, L. Qian, J. Zhou, H. Ouyang, X. Zou: Adv Healthc Mater Vol.6 (2017).

[13] K. Thunsiri, S. Udomsom, W. Wattanutchariya: KEM Vol.675-676 (2016), p.459.

[14] J. Tanum, S. Udomsom, W. Wattanutchariya, P. Sooksaen, F. Kantawong: KEM Vol.675-676 (2016), p.473.

DOI: 10.4028/www.scientific.net/kem.675-676.473

[15] R.A. Sun, H.H. Messer: Pediatr Dent Vol.12 (2012), p.303.

[16] K. Thunsiri, W. Wattanutchariya: AMM Vol.799-800 (2015), p.488.

[17] T.V.L. HimaBindu, M. Vidyavathi, K. Kavitha, T.P. Sastry, R.V. Suresh Kumar: Int. J. Drug Deliv. Vol.2 (2010).

[18] A. Vasconcelos, A.C. Gomes, P.A. Cavaco: Acta Biomater Vol.8 (2012), p.3049.

[19] S.M. Lee, I.K. Park, Y.S. Kim, H.J. Kim, H. Moon, S. Mueller, Y.I. Jeong: Biomater Res Vol.4 (2016), p.15.

[20] J.A. Fulton, K.N. Blasiole, T. Cottingham, M. Tornero, M. Graves, L.G. Smith, S. Mirza, E.N. Mostow: Adv Skin Wound Care Vol.25 (2012), p.315.

DOI: 10.1097/01.asw.0000416003.32348.e0

[21] A. Folestad, B. Gilchrist, K. Harding, E. de Laat, C. Lyder, S. Meaume, T. Phillips, P. Price, M. Romanelli, G. Sibbald, W. Vanscheidt, J. Verdú, K. Vowden, P. Vowden, W.C. Cheng, J. Contreras-Ruiz, X. Fu, P. Grocott, J.P. Hong, K. Matsuzaki, H. Sanada, V. Shukla, C. Song, M.L. Wai-kuen, M. Woodward: Int Wound J. Vol.5 (2008), Suppl 1:iii-12.

[22] Y. X. Wang, Y.P. Qin, Z.J. Kong, Y.J. Wang, L. Ma: AMR Vols. 887-888 (2014), p.541.

[23] P.O. Okolo, O.U. Akakuru, O.U. Osuoji, A. Jideonwo: Bajopas Vol. 6 (2013), p.118.