Synthesis and Characterization of Polycaprolactone(PCL)/Organo-Montmorillonite(O-MMT) Blendvia Solvent Casting

Abstract:

Polycaprolactone (PCL) is a hydrophobic, semi-crystalline polymer that has been broadly applied in long term implants, drug release applications, and in the tissue engineering field due to its availability, relatively inexpensive price and suitability for modification. Organo-montmorillonite (O-MMT) clay has been extensively used for various polymer-nanocomposite studies and widely used as adsorbent due to its high specific surface area. Most polymer clay nanocomposites are involved in biomedical applications such as in drug delivery systems and wound healing. In this study, O-MMT was incorporated to PCL via solvent casting, which resulted into film membranes that were characterized to identify its surface morphology, chemical structure, wettability, mechanical property, pore size, and antibacterial properties upon its varying concentrations. The SEM and FTIR results indicated the presence of both PCL and O-MMT within the membrane. The mechanical properties of the film membranes showed an improvement upon reaching an optimal point. An increase in pore size was determined relative to its hydrophilicity. The film membrane showed an antibacterial activity only at the higher concentrations of the O-MMT using the S. aureus strain. As such, the results showed that there is an improvement in the mechanical, wettability, water absorption and antibacterial properties of the PCL with the incorporation of the O-MMT, making it a viable candidate dressing material for wound healing.

• Periodical: Materials Science Forum (Volume 998)
• Pages: 255-260
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.998.255
• Online since: June 2020
• Authors: Rey Mark A. Ramos*, Ruth R. Aquino, Marvin S. Tolentino, Elisa G. Eleazar, Blessie A. Basilia
• Keywords: Film Membrane, Organo-Montmorillonite, Poly(Caprolactone), Polymer-Clay Nanocomposites, Solvent Casting

References

[1] K. Vowden and P. Vowden, Wound dressings: principles and practice,, Surgery (United Kingdom), vol. 35, no. 9. Elsevier Ltd, p.489–494, 01-Sep-(2017).

DOI: 10.1016/j.mpsur.2017.06.005

[2] D. Simões, S. P. Miguel, M. P. Ribeiro, P. Coutinho, A. G. Mendonça, and I. J. Correia, Recent advances on antimicrobial wound dressing: A review,, European Journal of Pharmaceutics and Biopharmaceutics, vol. 127. Elsevier B.V., p.130–141, 01-Jun-(2018).

DOI: 10.1016/j.ejpb.2018.02.022

[3] C. H. Zhou, Z. F. Shen, L. H. Liu, and S. M. Liu, Preparation and functionality of clay-containing films,, J. Mater. Chem., vol. 21, no. 39, p.15132–15153, Oct. (2011).

DOI: 10.1039/c1jm11479d

[4] M. C. Smita Mohanty, Effect of Different Solvents in Solvent Casting of Porous caffolds – In Biomedical and Tissue Engineering Applications,, J. Tissue Sci. Eng., vol. 06, no. 01, (2015).

DOI: 10.4172/2157-7552.1000142

[5] M. A. Woodruff and D. W. Hutmacher, The return of a forgotten polymer - Polycaprolactone in the 21st century,, Progress in Polymer Science (Oxford), vol. 35, no. 10. Elsevier Ltd, p.1217–1256, (2010).

DOI: 10.1016/j.progpolymsci.2010.04.002

[6] J. Ma, J. Xu, J. H. Ren, Z. Z. Yu, and Y. W. Mai, A new approach to polymer/montmorillonite nanocomposites,, Polymer (Guildf)., vol. 44, no. 16, p.4619–4624, Jul. (2003).

DOI: 10.1016/s0032-3861(03)00362-8

[7] A. Harrane and M. Belbachir, Synthesis of biodegradable polycaprolactone/ montmorillonite nanocomposites by direct in-situ polymerization catalysed by exchanged clay,, in Macromolecular Symposia, 2007, vol. 247, p.379–384.

DOI: 10.1002/masy.200750144

[8] S. Pisani, R. Dorati, B. Conti, T. Modena, G. Bruni, and I. Genta, Design of copolymer PLA-PCL electrospun matrix for biomedical applications,, React. Funct. Polym., vol. 124, p.77–89, Mar. (2018).

DOI: 10.1016/j.reactfunctpolym.2018.01.011

[9] S. Zymankowska-Kumon, M. Holtzer, E. Olejnik, and A. Bobrowski, Influence of the changes of the structure of foundry bentonites on their binding properties,, Medziagotyra, vol. 18, no. 1, p.57–61, (2012).

DOI: 10.5755/j01.ms.18.1.1342

[10] Y. Yuan and T.R. Lee, Contact angle and wetting properties. In Surface science techniques. (2013).

[11] C.M. Gribble et al., Porometry, porosimetry, image analysis and void network modelling in the study of the pore-level properties of filters,, Chem. Eng. Sci., p.1–9, (2011).

DOI: 10.1016/j.ces.2011.05.013