Functions and Future Applications of F1 ATPase as Nanobioengine - Powering the Nanoworld!

Abstract:

Recent nanotechnological revolution mandates astonishing imagination about future nanoworld. Nature has ability to create nanobiomolecules which can function in extraordinary way which can be used to produce nanohybrid systems. The opportunity to use such nanobiomolecules in combination of nanomechanical systems for development of novel nanohybrid systems for their various applications needs to explore in further nanotechnological development. F1 ATPase is a subunit of ATP synthase, which is one of the biomolecular structure works on the plasma membrane of the living cell. The reversible function of F1 ATPase gives a counterclockwise rotation of γ shaft by hydrolyzing ATP and the energy released in the form of rotational torque. This rotational torque of F1 ATPase can be used to power the functional movement of nanodevice. This feature article discusses comparisons of various biomolecular motors for their powering capacities, recent developments, presents new discoveries, experimentations on F1 ATPase and its novel imaginary futuristic applications where F1 ATPase could be used as nanobioengine for powering functional nanoworld.

• Periodical: Nano Hybrids (Volume 5)
• Pages: 33-53
• DOI: https://doi.org/10.4028/www.scientific.net/NH.5.33
• Online since: October 2013
• Authors: Sandip S. Magdum
• Keywords: F1 ATPase, Nanobioengine, Nanobiomolecules, Nanomechanical, Nanotechnology

References

[1] S. Abeer, Future Medicine: Nanomedicine, JIMSA 25 (2012)187-192.

[2] S. Furuike, M.D. Hossain, Y. Maki, K. Adachi, T. Suzuki, A. Kohori, H. Itoh, M. Yoshida, K. Kinosita, Axle-less F1-ATPase rotates in the correct direction, Science 319 (2008) 955-958.

DOI: 10.1126/science.1151343

[3] A. Lohrasebi, Y. Jamali, H. Rafii-Tabar, Modeling the effect of external electric field and current on the stochastic dynamics of ATPase nano-biomolecular motors, Physica A 387 (2008) 5466-5476.

DOI: 10.1016/j.physa.2008.05.030

[4] S. Yamaguchi, S. Matsumoto, K. Ishizuka, Y. Iko, K.V. Tabata, H.F. Arata, H. Fujita, H. Noji, I. Hamachi, Thermally Responsive Supramolecular Nanomeshes for On/Off Switching of the Rotary Motion of F1‐ATPase at the Single‐Molecule Level, Chemistry-A European Journal 14 (2008) 1891-1896.

DOI: 10.1002/chem.200701285

[5] S.M. Block, Kinesin: What Gives? Minireview, Cell 93 (1998) 5-8.

[6] M.J. Schnitzer, S.M. Block, Kinesin hydrolyses one ATP per 8-nm step, Nature 388 (1997) 386-390.

DOI: 10.1038/41111

[7] M.D. Wang, M.J. Schnitzer, H. Yin, R. Landick, J. Gelles, S.M. Block, Force and velocity measured for single molecules of RNA polymerase, Science 282 (1998) 902-907.

DOI: 10.1126/science.282.5390.902

[8] K. Kitamura, M. Tokunaga, A.H. Iwane, T. Yanagida, A single myosin head moves along an actin filament with regular steps of 5.3 nanometres, Nature 397 (1999) 129-134.

DOI: 10.1038/16403

[9] C. Montemagno, G. Bachand, S. Stelick, M. Bachand, Constructing biological motor powered nanomechanical devices, Nanotechnology 10 (1999) 225-231.

DOI: 10.1088/0957-4484/10/3/301

[10] G. Bachand, C. Montemagno, Constructing organic/inorganic NEMS devices powered by biomolecular motors, Biomedical Microdevices 2 (2000) 179-184.

[11] R. Yasuda, H. Noji, K. Kinosita, M. Yoshida, F1-ATPase Is a Highly Efficient Molecular Motor that Rotates with Discrete 120 Steps, Cell 93 (1998) 1117-1124.

DOI: 10.1016/s0092-8674(00)81456-7

[12] H. Noji, R. Yasuda, M. Yoshida, K. Kinosita, Direct observation of the rotation of F1-ATPase, Nature 386 (1997) 299-302.

DOI: 10.1038/386299a0

[13] R. Soong, G. Bachand, H. Neves, A. Olkhovets, H. Craighead, C. Montemagno, Powering an inorganic nanodevice with a biomolecular motor, Science 290 (2000) 1555-1558.

DOI: 10.1126/science.290.5496.1555

[14] A.A. Johnson, J. Lewis, M. Raff, K. Roberts, P. Walter, The cytoskeleton, in: M. Anderson, S. Granum (Eds.), Molecular Biology of the Cell, 5th edition, Garland science, Taylor & Francis Group, New York, 2007 p.1022.

[15] A.A. Johnson, J. Lewis, M. Raff, K. Roberts, P. Walter, The cytoskeleton, in: M. Anderson, S. Granum (Eds.), Molecular Biology of the Cell, 5th edition, Garland science, Taylor & Francis Group, New York, 2007 p.1025.

[16] Adapted from the Wikimedia Commons file "Image: Atp Synthase.png" [http://en.wikipedia.org/wiki/File:Atp_synthase.PNG]

[17] Y.M. Romanovsky, A.N. Tikhonov, Molecular energy transducers of the living cell. Proton ATP synthase: a rotating molecular motor, Physics-Uspekhi 53 (2010) 893.

DOI: 10.3367/ufne.0180.201009b.0931

[18] A.A. Johnson, J. Lewis, M. Raff, K. Roberts, P. Walter, Mechanisms of Cell Communication, in: M. Anderson, S. Granum (Eds.), Molecular Biology of the Cell, 5th edition, Garland science, Taylor & Francis Group, New York, 2007 p.943.

[19] G. Oster, H. Wang, Rotary protein motors, Trends in cell biology, 13 (2003) 114-121.

DOI: 10.1016/s0962-8924(03)00004-7

[20] D. Kaiser, Bacterial motility: How do pili pull? Current Biology 10 (2000) R777-R780.

DOI: 10.1016/s0960-9822(00)00764-8

[21] Image from the RCSB PDB (www.pdb.org) of PDB ID 1C17 (V.K. Rastogi, M.E. Girvin, Structural changes linked to proton translocation by subunit c of the ATP synthase, Nature,402 (1999) 263-268.

DOI: 10.1038/46224

[22] B. Maier, L. Potter, M. So, H. Seifert, M.P. Sheetz, Single pilus motor forces exceed 100 pN, PNAS 99 (2002) 16012-16017.

DOI: 10.1073/pnas.242523299

[23] G. Oster, H. Wang, Reverse engineering a protein: the mechanochemistry of ATP synthase. BBA 1458(2) (2000) 482-510.

DOI: 10.1016/s0005-2728(00)00096-7

[24] CSID:5742 on [http://www.chemspider.com/Chemical-Structure.5742.html]

[25] A.E. Senior, ATP synthase: Motoring to the finish line, Cell 130 (2007) 220-221.

DOI: 10.1016/j.cell.2007.07.004

[26] R. Garrett, C.M. Grisham, Biochemistry, Belmont, CA: Brooks/Cole, Cengage Learning 2010.

[27] Bald, ATP Synthase: Structure, Function and Regulation of a Complex Machine, in: G.A. Peschek et al. (Eds.), Bioenergetic Processes of Cyanobacteria, Springer, Netherlands, 2011, pp.239-261.

DOI: 10.1007/978-94-007-0388-9_10

[28] Reprinted (adapted) with permission from "H. Noji, Research of rotating molecule, ATP synthetase, Biohistory journal, Winter (2004)." Copyright 2004 JT Biohistory Research Hall. [http://www.brh.co.jp/en/seimeishi/journal/043/research_11.html]

[29] H. Noji, Research of rotating molecule, ATP synthetase, Biohistory Journal, Winter (2004). Website: http://www.brh.co.jp/en/seimeishi/journal/043/research_11.html

[30] W. Junge, H. Lill, S. Engelbrecht, ATP synthase: an electrochemical transducer with rotatory mechanics, Trends Biochem. Sci. 22 (1997) 420.

DOI: 10.1016/s0968-0004(97)01129-8

[31] P.D. Boyer, The ATP synthase-a splendid molecular machine, Annu. Rev. Biochem. 66 (1997) 717-749.

DOI: 10.1146/annurev.biochem.66.1.717

[32] K. Kinosita Jr., K. Adachi, H. Itoh, Rotation of F1-ATPase: How an ATP-driven molecular machine may work, Annu. Rev. Biophys. Biomol. Struct. 33 (2004) 245-268.

DOI: 10.1146/annurev.biophys.33.110502.132716

[33] S. Toyabe, E. Muneyuki, Nanosized free-energy transducer F1-ATPase achieves 100% efficiency at finite time operation, arXiv preprint arXiv: 1210.4017 (2012).

[34] G.D. Bachand, R.K. Soong, H.P. Neves, A, Olkhovets, H.G. Craighead, C.D. Montemagno, Precision attachment of individual F1-ATPase biomolecular motors on nanofabricated substrates. Nano Lett. 1 (2001) 42-44.

DOI: 10.1021/nl005513i

[35] D. Spetzler, R. Ishmukhametov, T. Hornung, L.J. Day, J. Martin, W.D. Frasch, Single molecule measurements of F1-ATPase reveal an interdependence between the power stroke and the dwell duration, Biochemistry 48 (2009) 7979-7985.

DOI: 10.1021/bi9008215

[36] A. Palanisami, T. Okamoto, Torque-induced slip of the rotary motor F1-ATPase, Nano Lett. 10 (2010) 4146-4149.

DOI: 10.1021/nl102414d

[37] T. Uchihashi, R. Iino, T. Ando, H. Noji, High-speed atomic force microscopy reveals rotary catalysis of rotorless F1-ATPase, Science 333 (2011) 755-758.

DOI: 10.1126/science.1205510

[38] Y. Ito, T. Oroguchi, M. Ikeguchi, Mechanism of the conformational change of the F1-ATPase β subunit revealed by free energy simulations, J. Am. Chem. Soc. 133 (2011) 3372-3380.

DOI: 10.1021/ja1070152

[39] E. Cabezon, V.F. Lanza, I. Arechaga, Membrane-associated nanomotors for macromolecular transport, Curr. Opin. Biotechnol. 23 (2012) 537-544.

DOI: 10.1016/j.copbio.2011.11.031

[40] Reprinted (adapted) with permission from "H. Choi, C. Montemagno, Artificial organelle: ATP synthesis from cellular mimetic polymersomes. Nano Lett. 5 (2006) 2538-2542.

DOI: 10.1021/nl051896e

[41] R. Segelken, Fantastic voyage: Tiny pharmacies propelled through the body could result from Cornell breakthrough in molecular motors, 1999 on [http://www.news.cornell.edu/releases/sept99/bio_nano_mechanical.hrs.html]

[42] R. Segelken, How Cornell scientists uncover and remake molecules of life. On [http://www.news.cornell.edu/chronicle/00/10.12.00/ss-molecules_of_life.html]

[43] Liu, S. Wang, W. Xu, Q. Liang, Bio-nano-robot and drug targeting delivery technology, Chinese Journal of Mechanical Engineering 44 (2008) 80-86.

DOI: 10.3901/jme.2008.11.080

[44] C. Kaparissides, S. Alexandridou, K. Kotti, S. Chaitidou, Recent advances in novel drug delivery systems, Journal of Nanotechnology Online 2 (2006) 1-11.

[45] C. Cunshe, L. Xiaojuan, Application of a biosensor for super sensitive detector of clenbuterol, N.Z. J. Agric. Res. 50 (2007) 689-695.

DOI: 10.1080/00288230709510339

[46] Q. He, L. Duan, W. Qi, K. Wang, Y. Cui, X. Yan, J. Li, Microcapsules containing a biomolecular motor for ATP biosynthesis, Adv. Mater. 20 (2008) 2933-2937.

DOI: 10.1002/adma.200800622

[47] K. Gilleo, The Sci-Fi Future of Medicine … the Next 50 Years. On [www.allflexinc.com/PDF/Future%20of%20Medicine.pdf]

[48] B. Alberts, Cell Biology: The Endless Frontier, Molecular Biology of the Cell 21(2010) 3785-3785.

DOI: 10.1091/mbc.e10-04-0334