Fabrication and Characterization of Biodegradable Nanospheres Containing Curcumin

Abstract:

Crucumin (diferuloylmethane) is a major active component of turmeric, but its bioavailability of oral administration is very low. In order to improve its pharmaceutical efficiency in oral use, poly (d,l-lactide) (PDLLA) nanospheres containing curcumin are successfully fabricated using a modified spontaneous emulsification solvent diffusion (SESD) method. The morphology, size and distribution of the resulting nanospheres are characterized by TEM and laser light scattering method. Drug contents in the nanospheres are calculated through UV spectrophotometer method. As a result, regular spherical PDLLA nanospheres containing curcumin are obtained and their effective diameters are 289 nm with narrow distribution (Pd=0.118)

• Periodical: Solid State Phenomena (Volumes 121-123)
• Pages: 767-770
• DOI: https://doi.org/10.4028/www.scientific.net/SSP.121-123.767
• Online since: March 2007
• Authors: Sheng Min Zhang, Rui Rui Cao, Jian Liu, L. Liu, P. Lu, W. Zhou, L. Cheng, P.P. Chen, Q.M. Luo
• Keywords: Curcumin, Degradable, Encapsulation, Nanospheres

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