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Synthesis of novel drug Benvitimod Jungang Gao1,a*, Yue Zhang1,2,b, Hetang Zheng2,c, Chunfang Wang2,d, Huixian Liu2,e and Shuchun Zhao2,f 1College of Chemistry and Enviromental Science, Hebei University, Baoding 071002, China 2School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China agaojg@hbu.edu.cn, byuezhang02@163.com, czhenght@hebust.edu.cn, dwangcf@hebust.edu.cn, eliuhx@hebust.edu.cn, fzhaoshuchunsun@163.com Keywords: Benvitimod; 3,5-dihydroxy-4-i-propylstilbene; reduction; oxidition; heterogeneous.
The product was characterized by 1H NMR and the spectra data was identical with that corresponding authentic sample.
Results of reduction entry substrate reductive agent solvent time (h) content (%)* yield (%) 1 2 3 4 5 4b 4b 4b 4a 4a LiAlH4 NaBH4+CH3OH NaBH4+ AlCl3 KBH4+BF3·Et2O NaBH4+I2 Ether THF THF THF THF 3 6 6 12 4 99 99 98 99 98 94 96 95 92 94 In the oxidation process from 5 to 6a, PCC was used in the original route.

Analysis of data in this research is based on ANOVA (Analysis Of Variance).
After reanalyzing of data (A, B and C) a modified linear model for spring-back was obtained: (3) d t v back Spring 0389000.0199000.0200000.0683400.0 − − + =− 2 R is coefficient of determination.
The higher 2 R , the better the model fits data.
Fig. 6: 2ormal probability plot of the effects Fig. 7: Pareto chart of the effects Fig. 8: Residuals versus run order 0 0.1 0.2 0.3 0.4 0.5 1 2 3 4 5 6 7 8 Test number Spring-back CMM data Model data Fig. 9: Comparison between CMM and modified model results Conclusion Important and vital results of this research can be summarized as follows: 1.
Increases of sheet thickness, tool diameter, feed rate and spindle speed; and reduction of vertical step size can lead to a reduction in spring-back, independently. 3.

Data acquisition was computer controlled and included tracking and leak loads, loading ram displacement, thermocouple emf, and test time.
X-ray diffraction data for uncoated specimens after cyclic fatigue testing showed no phase changes.
X-ray diffraction data of uncoated sides of the specimens clearly indicated the presence of the crystoballite phase.
In contrast, X-ray diffraction data of mullite-coated specimens after the static fatigue test indicated mullite and Si3N4 as main phases and a crystoballite as a secondary phase.
Summary of the Flexure Tests Data on AS800.

The complex of actions that leads to reduction of damages from buildings of thermal energy is listed, heating up to improvement of parameters of a microclimate in the operated rooms of the top floors of buildings.
average temperature of the coldest five-day week with security 0,92 according to Construction Norms and Regulations 23-01; – air temperature in rooms of a cold attic of the building, ºС; – the area, sq.m and the specified resistance to a heat transfer, sq.m • °C/W, protections between rooms heated in the building and rooms of a cold attic (garret overlapping, partitions between garrets and rooms of ladder marches, etc.); qpj – the linear density of a thermal stream through the thermal insulation surface, falling on 1 linear meter of length of the pipeline of a certain diameter taking into account heat losses through the isolated support, flange connections and fittings, W/m (for attics and cellars of qpj value depending on the nominal diameter of the pipeline and the average temperature of the heat carrier are provided in the tab. of 12 construction regulations 23–101); lpj – length of the pipeline of a certain diameter, m (for the operated buildings is accepted according to actual data
At preset values of temperatures external () and internal () air, the invariable geometrical sizes of the enclosing structures of a cold attic (,,) and the constant length of pipelines of systems of heating and hot water supply (), decrease in air temperature in rooms of a cold attic is provided with reduction of heatreceipts.
It is possible to achieve reduction of heatreceipts to rooms of a cold attic the following engineering actions: · warming of garret overlapping (increase sizes); · thermal insulation of pipelines of systems of heating and hot water supply (reduction of size ); · increase in air exchange in garrets (increase in value).
Besides a solution of the problem of formation ice built-up on buildings roofs with a cold attic, the listed complex of actions leads to reduction of losses by buildings of thermal energy by heating, to improvement of microclimate parameters in the operated rooms of the top floors of buildings.

The capacitance of model capacitors based on carbons obtained at different modes was calculated from both from cycling voltammetry and galvanostatic charge-discharge data.
Zview2 analytic software was used for impedance spectroscopy data analysis [23].
The equivalent circuit used for experimental impedance data fitting is presented in Fig. 7.
The fitted data for circuit elements calculated for zero bias potential are generalized in Table 2.
Maximal value of specific capacity (up to about 100 F/g) for carbons obtained at 600ºC corresponds to MC-075-600-2 sample which is consistent with CV data.

In this way, the motional data structure can be displayed clearly.
So the data projected into the subspace will change accordingly.
Nonlinear Manifold Learning for Data Stream.
Proceedings of SIAM Data Mining, p.33-44
A Robust Generalization of ISOMAP for New Data.

Based on Arduino data acquisition results, thinner IPMC (t1) has more than 5 times respond speed than thicker IPMC (t2).
Simultaneous data logging analysis and real time control experiment can be done without great hassle with Arduino microcontroller.
Real time control data logging can be provided by MATLAB/Simulink through ArduinoIO programming which already uploaded previously into Arduino memory.
Besides, instead of MATLAB/Simulink, open source and light softwares such as Processing and PLX-DAQ can be used for data logging which ultimately allow Arduino to achieve near to its maximum 10 KHz sampling rate.
Based on Arduino data acquisition, thinner IPMC (t1) have more than 5 times respond speed than thicker IPMC (t2).

It allows to control defined specimen motion, continuous data recording from the 2D laser profile scanner, obtained data pre-processing (profiles averaging, filtration, etc.) and after that their saving to the resulting data matrix.
The final specimen’s topography can be also displayed using this software and some additional operations can be performed (cutting off the monitored area, rendering 2D and 3D surfaces, saving results in different data formats, etc.).
The issues connected with choosing the distance between the obtained line profiles should be solved with respect to achieving a compromise between the expected measurement accuracy, the amount of processed and evaluated data and the technical difficulty of designed measurement system.
The resulting determination of the fracture surface area from the obtained data was solved by a simple algorithm which allows to quantify the approximate area between the four neighbouring points of the data matrix (z-axis) by the dividing of the resulting pattern into two triangles in a 3D coordinate system.
The increasing maximum temperatures in furnace in the range between 550 to 1000 °C led to a significant reduction of the modulus of elasticity value, a slight reduction of fracture toughness value and a significant increase of fracture energy values.

To accelerate the process, it was decided to develop a program that will calculate the dimensionless function based on user input of the experimental data [15], [16], [17].
The output data are: Rational amount of powder and Evaluation of the effectiveness of the solution. 2.
Such data are: Information about the properties of nanopowder, base metal, welding regimes.
After the analysis of the input data has been completed, the processed data passing under the user's requirements will be transferred to the calculation stage. 3.
At the calculation stage, based on the analyzed data, the value of the dimensionless function is calculated: f =s∙e v where the thickness of the dendrite is s (μm); the width of the dendrite is e (μm); the volume of a drop of electrode metal is v (mm3).

A thin surface-near layer, which is highly N-doped during the chemical vapour deposition growth, leads to a reduction of DIT only close to the conduction band edge.
peak position (cm -3) 30 min anneal at 1500°C in Ar max. peak position/in-situ N-doped layer dmax (nm) consumed SiC-layer dcons (nm) UFB (V) integrated DIT (cm -2) (EC - (0.1 to 0.6 eV)) #1 not-implanted - - 46 +2.4 2.7 x 10 13 #2 2 x 1017 no 30 46 +1.5 2.4 x 1013 #3 7 x 1017 no 30 46 -0.1 ≈ 8 x 1012 #4 1 x 1018 no 30 46 -1.5 ≈ 3 x 1012 #5/5a 3 x 1018 no/yes 30 46 -9.4 7.5 x 109 #6/6a 7 x 1018 no/yes 30 46 -14.1 6.5 x 1011 #7/7a 1 x 1019 no/yes 30 46 -30 4.6 x 1011 #8 3 x 1019 yes 45 45 < -40 no data #9 3 x 1019 yes 45 90 -5.4 6.0 x 1010 #10 in situ, 3 x 1018 - 30 12 +1.2 ≈ 2 x 1013 #11 in situ, 3 x 1018 - 30 39 +2.6 2.2 x 1013 MOS capacitors.
The corresponding curves of sample #11 in Figs. 2 and 3 (see squares) show no large shift of the flat-band voltage and a reduction of DIT only close to the conduction band edge (reduction of NITs).