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Synthesis and H+/K+-ATPase Inhibitory Activity of 2-Phenyl-6,7-Dihydrobenzofuran-4(5H)-one Oxime Ether Derivatives

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Abstract:

Three pairs of 2-phenyl-6,7-dihydrobenzofuran-4(5H)-one oxime and corresponding oxime ether isomers were synthesized and separated as potential anti-ulcer agent. Their structures were characterized by NMR, IR, ESI-MS and elemental analysis. Preliminarily H+/K+-ATPase activity evaluation indicated that all the target compounds had a better inhibitory effect than the commercial omeprazole with the IC50 of 2.0~30.0 μM.

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Periodical:

Advanced Materials Research (Volumes 634-638)

Pages:

1192-1195

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.634-638.1192

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Online since:

January 2013

Authors:

Hu Biao Fang, Lei Jin, Wei Chen Zai, Yu Rong Song, Jun Zhi Wang, Nian Yu Huang

Keywords:

2-Phenyl-6,7-Dihydrobenzofuran-4(5H)-One, H+/K+-Atpase Inhibitory Activity, Oxime Ether, Structure Elucidation, Synthesis

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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