Synthesis and Fungicidal Activity of Novel N-Nitro-2-Pyrimidinamine Derivatives

Abstract:

Two series of novel N-nitro-2-pyrimidinamine derivatives were synthesized from ethyl acetoacetate, dimethyl malonate and nitroguanidine with good yields and high efficiency. The fungicidal activities of the synthesized compounds against nine fungal species were studied both in vitro and in vivo. Some of these compounds like 4,6-dihydr oxy -N-nitro-2-pyrimidinamine and 4,6-dihydroxy-5-isopentyl-N-nitro-2-pyrimidinamine showed obvious inhibitory of the mycelium growth at 50 mg/L. The structure-activity relationship of these compounds was also discussed.

• Periodical: Advanced Materials Research (Volumes 634-638)
• Pages: 1184-1191
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.634-638.1184
• Online since: January 2013
• Authors: Wen Yan Qu, Jian Zhao, Bei Bei Gao, Shuo Chen, Zhi Fu Jiang, Jun Ning, Hui Zhu Yuan, Dong Mei She
• Keywords: Fungicidal Activity, N-Nitro-2-Pyrimidinamine, Structure-Activity, Synthesis

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