Synthesis and Characterization of 4-(3′-Chlorophenylamino)-6-Methoxy Quinazoline Derivatives

Abstract:

Five compounds of 4-(3-Chlorophenylamino)-6-methoxy quinazoline compounds, including 7-(3-(o-tolyloxy)propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine,7-(3-(m-tolyloxy) propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine,7-(3-(p-tolyloxy)propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine,7-(3-(2,6-dimethylphenoxy)propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine,7-(3-phenoxypropoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine,were synthesized from N′-(5-(3-chloropropoxy)-2-cyano- 4-methoxyphenyl)- N, N-dimethylformamidine by cyclization，etheration, in the yield of 68.3%、53.8%、61.4%、75.6% and 87.4% respectively. Their structures were characterized by IR, 1H NMR, 13C NMR, MS and elemental analysis.

• Periodical: Advanced Materials Research (Volumes 634-638)
• Pages: 1215-1218
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.634-638.1215
• Online since: January 2013
• Authors: He Ping Yan, Du Shu Huang, Ju Cheng Zhang
• Keywords: 4-(3′-Chlorophenylamino)-6-Methoxy Quinazoline, Quinazoline Derivatives, Synthesis

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