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A New Approach for the Synthesis of 6,7-Dihydro-5H-Cyclopenta[b]pyridine

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Abstract:

A new practical and efficient route was developed for the synthesis of 6,7-dihydro-5H-cyclopenta[b]pyridine, which is a key intermediate of cefpirome. Leading to the formation of the corresponding product, nucleophilic addition, acetylization, Vilsmeier cyclization reaction and dechlorination were employed under mild reaction conditions by using commercially available cyclopentanone and benzylamine as raw materials. The total yield of this newly developed synthetic route for the target product was 43.15% with 99.7% of purity (HPLC). The structure of target molecular was confirmed by LC-MS and 1H NMR spectrum.

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Periodical:

Advanced Materials Research (Volumes 634-638)

Pages:

1211-1214

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.634-638.1211

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Online since:

January 2013

Authors:

Jin Hua Zhou, Hai Li Gao, Han Zhou Sun, Yu Xiong Wu

Keywords:

6,7-Dihydro-5H-Cyclopenta[b]pyridine, Cefpirome, Synthesis, Vilsmeier Reaction

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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