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Bioassay-Guided Isolation and Identification of a Acetylcholinesterase Inhibitors from Calophyllum polyanthum

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Abstract:

A significant acetylcholinesterase inhibitory activity was observed for the Ethanolic extract from the leaves of Calophyllum polyanthum by using TLC bioautographic method. Further bioassay-guided isolation of this extract using TLC bioautographic method resulted in obtaining a pyranochromanone, apetalic acid (1). The structure of 1 was identified by comparison of it’s spectral characteristics with previous reports. The concentration required for 50% inhibition of 1 was 0.95 mM, determined by a microplate assay. The anti-acetylcholinesterase aity of compound 1 was weak, but it was the first pyranochromanone which have anti-acetyl cholinesterase activity. As a new leading compound, it can be modified and transformed to obtain more potently active compounds.

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Periodical:

Advanced Materials Research (Volumes 634-638)

Pages:

1225-1228

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.634-638.1225

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Online since:

January 2013

Authors:

Fei Zhang, Hai Wei Ren, Yong Gang Wang, Rong Wang, Jie Sheng

Keywords:

Acetylcholinesterase Inhibitor, Apetalic Acid, Calophyllum polyanthum, Pyranochromanone, TLC Bioautographic Method

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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