Paper Titles
Production and Characterization of Biodegradable Plastics Based on Starch of Artocarpus heterophyllus Lam Seeds
p.263
Characteristics of Mg-Ca-Zn Alloy Metallic Foam Based on Mg-Zn-CaH2 System
p.267
The Effect of Repeated Impingement on UHMWPE Material in Artificial Hip Joint during Salat Activities
p.272
Simple and Easy Method to Synthesize Chicken Eggshell Based Hydroxyapatite
p.276
Synthesis of Chitosan-Gold Nanoparticles for Drug Delivery
p.280
Synthesis of Hydroxyapatite Nanoparticle from Tutut (Bellamya javanica) Shells by Using Precipitation Method for Artificial Bone Engineering
p.284
Adsorption of Lead Ions onto Citric Acid Modified Rubber (Hevea brasiliansis) Leaves
p.288
Effect of Deacetylation on Characterization of pH Stimulus Responsive Chitosan-Acrylamide Hydrogels Using Radiation
p.292
Synthesis of Smart Biodegradable Hydrogels Cellulose-Acrylamide Using Radiation as Controlled Release Fertilizers
p.296

Synthesis of Chitosan-Gold Nanoparticles for Drug Delivery

Article Preview

Abstract:

Gold nanoparticles (Au NPs) have potential applications in catalysis, drug delivery, sensors and environmental remediation. This wide range application is due to its amenability of synthesis and functionalization, less toxicity and ease of detection. The present work focuses on functionalization of Au NPs with chitosan for further application in biomedical research. Gold nanoparticles (Au NPs) functionalized chitosan were prepared by reducing gold salt solution at various pH medium in the presence of sodium borohydride. The effect of pH and chitosan concentration on the Au particle size and distribution are studied. The results revealed the dependence of Au particle size on the pH of the solution. The smallest Au particle size is found to form in a range of 10.22 ± 2.96 nm at 0.2% chitosan concentration. In this study, we anticipate the Au NPs functionalized chitosan can be used for drug delivery applications.

You might also be interested in these eBooks
Advanced Materials Science and Technology View Preview

Info:

Periodical:

Advanced Materials Research (Volume 896)

Pages:

280-283

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.896.280

Citation:

Cite this paper

Online since:

February 2014

Authors:

Hanani Yazid, Amirah Mohd Yassin, Ahmad Zahid Ruslan, Siti Hajar Alias, Rohana Adnan, Abdul Mutalib Md Jani*

Keywords:

Chitosan, Drug Delivery, Gold Nanoparticle

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2014 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

* - Corresponding Author

References

[1] H. Yazid, R. Adnan, M.A. Farrukh, S.A. Hamid, Synthesis of Au/Al2O3 nanocatalyst and its application in the reduction of p-nitrophenol, J. Chin. Chem. Soc. 58 (2011) 1-8.

DOI: 10.1002/jccs.201190093

Google Scholar

[2] A.M. Alkilany, L.B. Thompson, S.P. Boulos, P.N. Sisco, C.J. Murphy, Gold nanorods: their potential for photothermal therapeutics and drug delivery, Adv. Drug Delivery Rev. 64 (2012) 190-199.

DOI: 10.1016/j.addr.2011.03.005

Google Scholar

[3] H. Otsuka, Y. Nagasaki, K. Kataoka, PEGylated nanoparticles for biological and pharmaceutical applications, Adv. Drug Delivery Rev. 64 (2012) 246–255.

DOI: 10.1016/j.addr.2012.09.022

Google Scholar

[4] V. Pokharkar, D. Bhumkar, K. Suresh, Y. Shinde, S. Gairola, S. Jadhav, Gold nanoparticles as a potential carrier for transmucosal vaccine delivery, J. Biomed. Nanotechnol. 7 (2011) 57-59.

DOI: 10.1166/jbn.2011.1200

Google Scholar

[5] D.R. Bhumkar, H.M. Joshi, M. Sastry, V.B. Pokharkar, Chitosan reduced gold nanoparticles as novel carriers for transmucosal delivery of insulin, Pharm. Res. 24 (2007) 1415-1426.

DOI: 10.1007/s11095-007-9257-9

Google Scholar

[6] S. Ivanova, C. Petit, V. Pitchon, A new preparation method for the formation of gold nanoparticles on an oxide support, Appl. Catal. A: Gen. 267 (2004) 191-201.

DOI: 10.1016/j.apcata.2004.03.004

Google Scholar

[7] T.K. Sau and C.J. Murphy, Room temperature, high-yield synthesis of multiple shapes of gold nanoparticles in aqueous solution, J. Am. Chem. Soc. 126 (2004) 8648-8649.

DOI: 10.1021/ja047846d

Google Scholar

[8] R. Singh and J.W. Lillard Jr, Nanoparticle-based targeted drug delivery, Exp. Mol. Pathol. 86 (2009) 215-223.

Google Scholar