Paper Titles
Evaluation of RGD-Grafted Porous PLLA Scaffold for Chondrogenic Differentiation of Stem Cells
p.297
Thermosensitive and Cell-Adhesive Pluronic Hydrogels for Human Adipose-Derived Stem Cells
p.301
Laminin Immobilized on Titanium Oxide Films for Enhanced Human Umbilical Vein Endothelial Cell Adhesion and Growth
p.305
In Vitro Studies of Macrophage Biological Behavior on Cardiovascular Biomaterials
p.309
In-Stent Restenosis in the Rabbit Common Carotid Arteries Organ Culture
p.313
Effect of Rapamycin/Curcumin Co-Loaded Poly(Lactide-Co-Glycolide) Films on Blood Compatibility and Vascular Smooth Muscle Cell Proliferation
p.317
Characterization of the Gel-Spun Tubular Scaffold for Cardiovascular Tissue Engineering
p.321
Preparation and In Vitro Evaluation of Nerve Conduit Using Electro-Spun Biodegradable Polymers
p.325
Chitosan/Heparin Polyelectrolyte Complex Nanoparticles (100~200nm) Covalently Bonded with PEI for Enhancement of Chondrogenic Phenotype
p.329

In-Stent Restenosis in the Rabbit Common Carotid Arteries Organ Culture

Article Preview

Abstract:

In-stent restenosis is the result of a healing process that induces neointimal hyperplasia though mechanisms that are still not understood. The purpose of this study was to analyze the early histologic consequences and the kinetics of the healing process for a 72-hours period after stent implantation in an organ culture model. MTT-tests show that the vessel could maintain activity in the organ culture system. The vessel with stent had a different morphology and inflammatory molecule release compared with the normal vessel. So there could have direct relationships between inflammatory release and neointimal hyperplasia. The organ culture system can provide valuable information for studies of in-stent restenosis after stent implantation, especially for evaluation of new stents, such as drug-coated or other surface-modified stents.

You might also be interested in these eBooks
Advanced Biomaterials VII View Preview

Info:

Periodical:

Key Engineering Materials (Volumes 342-343)

Pages:

313-316

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.313

Citation:

Cite this paper

Online since:

July 2007

Authors:

Hai Yan Zhang, An Sha Zhao, Shan Fan, Jun Ying Chen, Nan Huang

Keywords:

Inflammation, Instent Restenosis, Organ Culture, Stent

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2007 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

References

[1] D.R. Holmes, R.E. Vlietstra and H.C. Smith. Am J Cardiol: 53 (1984) p.77.

Google Scholar

[2] V. Rainer, V. Jorn and Regine Baur. Atherosclerosis: 144 (1999) p.123.

Google Scholar

[3] A.W. Clowes, M.J. Karnovsky. Nature: 265(1977) p.625.

Google Scholar

[4] J.S. Powell, J.P. Clozel and R.K.M. Muler. Science: 245 (1989) p.186.

Google Scholar

[5] R.L. Geary, N. Koyama and T.W. Wang. Circulation: 91 (1995) p.2972.

Google Scholar

[6] C.L. Jackson. Trends Cardiovasc Med: 4 (1994) p.122.

Google Scholar

[7] M. LaBarbera. Science: 249 (1990) p.992.

Google Scholar

[8] L. Langille, F. O'Donnell. Science: 231 (1986) p.405.

Google Scholar

[9] B. Liu, Z. L Jiang and Y. Zhang. Journal of medical biomechanics: 16 (2001) p.4.

Google Scholar

[10] G.P. Frederick, R. Campbell. Arterioscler Thromb Vasc Biol: 22 (2002) p.1769.

Google Scholar

[11] L. Sachs. 6th edn. Berlin: Springer. 230 (1984) p.5.

Google Scholar

[12] R. Voisard, J.V. Eicken and R. Baur. Atherosclerosis: 144 (1999) p.123.

Google Scholar

[13] C.M. Holt, S.E. Francis and S. Cardiovasc Res: 26 (1992) p.1189.

Google Scholar

[14] P. Guérin, F. Rondeau and G. Grima. J. Vasc Res: 41 (2004) p.46.

Google Scholar

[15] P.D. Dobrin, F.N. Littoy and E.D. Endean. Surgery: 105 (1989) p.393.

Google Scholar