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Hydrophobically Modified Amphiphilic Cylodextrins as Novel Carriers for Controlled Delivery of Water-Soluble Drugs

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Abstract:

Hydrophobically modified derivative of a γ-cyclodextrin, functionalized with perfluoro alkyl ester group, was prepared and investigated for its potential use as a sustained release carrier for water-soluble drug molsidomine, a peripheral nitrovasodilator used in the treatment of angina pectoris. The molecular encapsulation of molsidomine by the amphiphilic cyclodextrin, octakis(6-O-perfluorobutanoyl)-γ-cyclodextrin (γ-CyD-F), was confirmed by DSC and XRD studies. The in-vitro release of molsidomine from peanut oil suspensions into aqueous phase was found to be significantly retarded by the complexation with γ-CyD-F, mainly due to the hydrophobic properties of the γ-CyD-F.

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Periodical:

Key Engineering Materials (Volumes 342-343)

Pages:

493-496

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.493

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Online since:

July 2007

Authors:

Hullathy Subban Ganapathy, Min Young Lee, Min Hee Woo, Yeong Tae Jeong, Kwon Taek Lim

Keywords:

Amphiphilic Cyclodextrins, Controlled-Release, Drug Delivery, Inclusion Complex, Perfluoroalkyl Ester, Water Soluble Drugs

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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