The virtual prototype model of the coal screen is established with Pro/E and RecurDyn based on virtual prototype technology. The kinematic characteristics of different points are obtained by simulation. At the same time, the finite element analysis model of a screen box is established with ANSYS. Modal analysis and harmonic analysis have been carried out based on dynamic analysis technology. According to the results of dynamic finite element simulation, some corresponding improvements were made for the structure of screen box, which makes the stress concentration region of screen box decreased and more uniform stress distribution to meet the design requirements.