Preparation and Properties of Nanocomposite of Poly(L-Lactide) and Surface Grafted Hydroxyapatite

Abstract:

nanocomposites of poly (L-lactide) (PLLA) and hydroxyapatite (HAP) or surface grafted hydroxyapatite (g-HAP) were prepared by ultrafines hot-pressing method, and the properties were investigated by polarized optical microscopy (POM), scanning electron microscopy (SEM), mechanical test and cell culture. Results showed that the PLLA segment grafted onto the HAP surface played a positive role on improving the interfacial compatibility between the g-HAP and the PLLA matrix. Compared with the HAP/PLLA composites, the bending strength and bending modulus of the g-HAP/PLLA composites were obviously enhanced, which was proportional to the n_HAP:n_L-LA ratio. The result of POM showed that the g-HAP particles acted as an effective heterogeneous nucleating agent in the g-HAP/PLLA composite. Fibroblasts culture indicated that the g-HAP/PLLA composites had better cytocompatibility than PLLA and HAP/PLLA composites. Hence, g-HAP/PLLA composites will be a promising material for bone tissue engineering.

• Periodical: Applied Mechanics and Materials (Volume 108)
• Pages: 238-243
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.108.238
• Online since: October 2011
• Authors: Bing Hong Luo, Jing Yang, Chung En Hsu, Jian Hao Zhao, Chang Ren Zhou
• Keywords: Hydroxyapatite (HAP), Nanocomposite, Poly(L-Lactide), Surface Grafting

References

[1] K. J. L. Burg, S. Porter and J. F. Kellam, Biomaterial developments for bone tissue engineering, Biomaterials, vol. 21, pp.2347-2359, December (2000).

DOI: 10.1016/s0142-9612(00)00102-2

[2] Y. Cui, Y. Liu, Y. Cui, X. Jing, P. Zhang and X. Chen, The nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with l-lactic acid oligomer for bone repair, Acta Biomaterialia, vol. 5, pp.2680-2692, September (2009).

DOI: 10.1016/j.actbio.2009.03.024

[3] A. V. Imbronito, A. Scarano, G. Orsini, A. Piattelli and V. E. Arana-Chavez, Ultrastructure of bone healing in defects grafted with a copolymer of polylactic/polyglycolic acids, Journal of Biomedical Materials Research - Part A, vol. 74, pp.215-221, August. (2005).

DOI: 10.1002/jbm.a.30350

[4] M. Kikuchi, Y. Suetsugu, J. Tanaka and M. Akao, Preparation and mechanical properties of calcium phosphate/copoly-L-lactide composites, Journal of Materials Science: Materials in Medicine, vol. 8, pp.361-364, June (1997).

DOI: 10.1023/a:1018580816388

[5] S. Verrier, J. J. Blaker, V. Maquet, L. L. Hench and A. R. Boccaccini, PDLLA/Bioglass composites for soft-tissue and hard-tissue engineering: an in vitro cell biology assessment, Biomaterials, vol. 25, pp.3013-3021, July (2004).

DOI: 10.1016/j.biomaterials.2003.09.081

[6] M. J. Mondrinos, R. Dembzynski, L. Lu, V. K. C. Byrapogu, D. M. Wootton, P. I. Lelkes and J. Zhou, Porogen-based solid freeform fabrication of polycaprolactone-calcium phosphate scaffolds for tissue engineering, Biomaterials, vol. 27, pp.4399-4408, September (2006).

DOI: 10.1016/j.biomaterials.2006.03.049

[7] T. Douglas, E. Pamula, D. Hauk, J. Wiltfang, S. Sivananthan, E. Sherry and P. H. Warnke, Porous polymer/hydroxyapatite scaffolds: Characterization and biocompatibility investigations, Journal of Materials Science: Materials in Medicine, vol. 20, pp.1909-1915, September (2009).

DOI: 10.1007/s10856-009-3756-7

[8] Nejati E, Mirzadeh H, Zandi M. Synthesis and characterization of nano-hydroxyapatite rods/poly(l-lactide acid) composite scaffolds for bone tissue engineering, Composites Part A: Applied Science and Manufacturing, vol. 39, no. 10, pp.1589-1596, May (2008).

DOI: 10.1016/j.compositesa.2008.05.018