Facilitating the alteration of the pharmacokinetics and pharmacodynamics of variety of drugs, nanoparticles are sort of particulate systems with the potential to minimize their ill-effects and increase the therapeutic benefit of the drug molecules in the human body. These particles deliver the drug at a specific target and help to keep the drug intact in the systemic circulation. According to previous studies, drug delivery system via nanoparticles has application in treatment of tuberculosis. With the understanding of chemotherapy in tuberculosis, the article highlights the considerable potential of nanoparticles in the treatment for MDR tuberculosis. We would also like discuss briefly on nanoDN`A-Biosensors through this article.