Modeling and simulating of human musculoskeletal system is an important and challenging problem. This paper is aimed to build a computational platform to conquer this problem based on the China digital human project. First the 3D anatomical models of human musculoskeletal system were reconstructed and integrated. Second, the finite element models of human skeleton system were built. In the end, a computational platform, which integrated the models and six related analysis modules, was developed to model and simulate human musculoskeletal system. A case study of subject’s gait was implemented to demonstrate that this computational platform had potential in research of human musculoskeletal biomechanics.