Chiral Separation of Non-Natural Carboxylic Amino Acid by Capillary Electrophoresis with CD Derivations as Chiral Selective Material

Bao Hui Li; Bao Juan Tian

doi:10.4028/www.scientific.net/AMM.130-134.4126

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vols. 130-134Chiral Separation of Non-Natural Carboxylic Amino...

Chiral Separation of Non-Natural Carboxylic Amino Acid by Capillary Electrophoresis with CD Derivations as Chiral Selective Material

Abstract:

A capillary electrophoresis (CE) method for the separation of four kinds of enantiomers of non-natural carboxylic amino acid was built while hydroxypropyl-β-cyclodextrin (HP-β-CD) derivations as chiral selective material. Several different β-CD derivatives were tested for the chiral separation of non-natural carboxylic amino acid, and it was proved that HP-β-CD could show better chiral selectivity. The separation of enantiomers of amino acid was obtained by CE in a 50-μm i.d.×60 cm (effective length 45 cm) fused-silica capillary at 18 kV voltage, while 10 mM phosphate acted as running buffer and HP-β-CD served as selective material. The detective wavelength was set at 254 nm.

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Periodical:

Applied Mechanics and Materials (Volumes 130-134)

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4126-4129

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https://doi.org/10.4028/www.scientific.net/AMM.130-134.4126

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October 2011

Authors:

Bao Hui Li, Bao Juan Tian

Keywords:

Capillary Electrophoresis, Carboxylic Amino Acid, Chiral Selective Material, Isomer Separation, Non-Natural

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