Association between Genetic Polymorphisms of 5,10-Methylenetetrahydrofolate Reductase and Cytokinesis-Block Micronucleus in Peripheral Blood Lymphocyte among 1,3-Butadiene Workers

Abstract:

Exploring the associations between genetic polymorphisms and susceptibility of chromosomal damage induced by 1,3-butadiene(BD) is of much importance for understanding BD carcinogenesis. In current study, we investigated the effects of MTHFR polymorphisms and MTHFR gene haplotype pairs on chromosome damage detected by the cytokinesis-block micronucleus (CBMN) assay in peripheral blood lymphocytes. The data showed that the frequencies of CBMN among BD-exposed workers were significantly associated with the MTHFR A1298C polymorphism (P=0.04 and P=0.03, respectively) by multivariate analysis of covariance. The foundings also showed that the haplotype pairs in the MTHFR gene were more likely than single SNPs to correlate with the BD-induced chromosome damage among occupational exposed workers. Gene-environment interactions between occupational BD exposure and polymorphisms of MTHFR were also evident. These results indicate that the MTHFR polymorphisms may play a role in sensitivity or genetic susceptibility in genotoxic effects of BD exposure in the occupational exposure population.

• Periodical: Applied Mechanics and Materials (Volume 273)
• Pages: 478-482
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.273.478
• Online since: January 2013
• Authors: Nan Liu, Xue Sheng Wang, Juan Cheng, Jing Wei Xiao, Bin Li
• Keywords: 1,3-Butadiene, CBMN Test, Haplotype, MTHFR, Polymorphism

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