A Review on Research of the Sustained Release Drug Delivery System Based on Magnesium Aluminate Layered Double Hydroxide

Abstract:

This paper reviewed our research progress in respects of th intercalation law of acetylsalicylic acid (ASP) with magnesium aluminate layered double hydroxide (LDH), the drug release mechanism and the tablet preparation effect of LDH-ASP system. We also discussed the propositions about the composite assembly rules, slow-release mechanism, and dosage form processing of the layered double hydroxide drug delivery system. Intercalation way and drug structure should be taken into consideration in assembly LDH-drugs system. The characteristic parameter of the composite LDH-drug reflected finely their loading efficiency and correlated definitely with drug release property. It had been found that the release rate and extent of intercalated drug was closely linked to the retarding status of LDH interlayer, which was dependent on the exchange mole ratio of n(drug) with n[H_nPO₄^(3-n)-]. In addition, the grafting reaction and phase transformation degree of LDH layer was hinged on the acidity of solution. The slow-release function of the LDH-drug system could be improved significantly by compositing with dextran (DET). A sustained-release skeleton tablet was producted with DET-LDH-ASP drug delivery system and hydrophilic gel material HPMC, which could effectively overcome the "first pass effect" and " burst release problem" of LDH-drug oral agents. The slow-release effect of LDH drug delivery system could be ulteriorly improved in systemic circulation environments, attributed to the triple control of HPMC-DET-LDH, DET-LDH-drugs three-level supramolecular assembly and the special circulation in vivo. Key words: Layered double hydroxide, Supramolecular assembly, Release control, Slow controlled release drug delivery system

• Periodical: Applied Mechanics and Materials (Volume 320)
• Pages: 495-504
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.320.495
• Online since: May 2013
• Authors: Guo Jing Gou, Li E Dong, Feng Juan Bao, Zhi Yu Wang, Lin Jiao, Jie Huang, Yue Sun, Bing Xue
• Keywords: Layered Double Hydroxides (LDHs), Release Control, Slow Controlled Release Drug Delivery System, Supramolecular Assembly

References

[1] P.X. Zhi, H.Z. Qing, Q.L. Gao and B.Y. Ai: Chemical Engineering Science, Vol. 61 (2006) No.3, p.1027.

[2] L. Katharina, P.X. Zhi and Q.L. Gao: Expert Opin. Drug Deliv, Vol. 6 (2009) No.9, p.907.

[3] N. Doi, S. Nitta, M. Kusakari and N. Takahashi: J. Patent 60,255,719.(1985).

[4] A. Khan, L. Lei, A.J. Norquist and D. O'hare: Chem Commun, 2001, No.22, p.2342.

[5] V. Ambrogi, G. Fardella, G. Grandolini and L. Perioli: Int J Pharm, Vol. 220 (2001) No.1-2, p.23.

[6] C.R. Gordijo, C.A. Barbosa, A. Ferreira: J Pharm Sci , Vol. 94 (2005) No.5, p.1135.

[7] P. Gunawan, R. Xu: J Pharm Sci, Vol. 97 (2008) No.10, p.4367.

[8] J.M. Oh, S.J. Choi, S.T. Kim and J.H. Choy: Bioconjug Chemistry, Vol. 17 (2006) No.6, p.1411.

[9] J.H. Choy, J.S. Jung and J.M.Oh: Biomaterials, Vol. 25 (2004) No.15, p.3059.

[10] J.M. Oh, M. Park and S.T. Kim:J Phys Chem Solids, Vol. 67 (2006) No.5-6, p.1024.

[11] H. Del: Appl Clay Sci. Vol. 36 (2007) No.1-3, p.103.

[12] G.J. Gou, F.J. Bao, H.Q. Yao, Z.X. Zheng and H.P. Xu: Functional Materials, Vol. 39 (2008) No.supplement, p.495.

[13] G.J. Gou, H.P. Xu, F.J. Bao: Journal of Salt Lake Research, Vol. 16 (2008) No.4, p.9.

[14] G.J. Gou, F.J. Bao, Z.X. Zheng, H.P. Xu: Chemical Research and Application, Vol. 20 (2008) No.9, p.1158.

[15] G.J. Gou, H.P. Xu, F.J. Bao, J.P. Liu:Chemical Research and Application, Vol. 21 (2009) No.1, p.56.

[16] G.J. Gou, H.P. Xu, J.P. Liu: Acta Chimica Sinica. Vol. 67 (2009) No.1, p.65.

[17] G. Alberti, U. Costantino: Layered Solids and Their Intercalation Chemistry (Oxford: Elsevier Science Press, England 1996, p.1).

[18] F.J. Bao, S.J. Wang, G.J. Gou, N.Q. Lu: Chemical Research and Application, Vol. 22 (2010) No.1, p.47.

[19] U. Costantino, M. Cascioia, L. Massinelli, M. Nocchetti and R. Vivani: Solid State Ionics, Vol. 97 (1997) No.1, p.203.

DOI: 10.1016/s0167-2738(97)00043-x

[20] G.J. Gou, F.J. Bao, H.P. Xu and Z.X. Zheng: Acta Physico-Chimica Sinica, Vol. 24 (2008) No.9, p.1675.

[21] B. Li, J. He, D.G. Evans and X. Duan: Int J Pharm, Vol. 287 (2004) No.1-2, p.89.

[22] L. Jiao. Preparation of DET-LDH-ASP hydrogel matrix sustained-released tablets and its pharmacokinetics( MS., Ningxia medical university, China 2011).p.1.

[23] L. Jiao, G.J. Gou, J.H Yang, X.P. Yang, Y.S. Zhu, Q.S. Yan, J.P. Liu and J. Li:Chinese Pharmaceutical Journal, Vol. 46 (2011) No.5, p.357.

[24] G.j. Gou, L. Jiao: Chinese .Patent 102,218,043A [P].( 2011).