Synthesis and Cytotoxic Activity of Salicyloyl Hydrazone Derivatives

Xiao Yang Qiu; An Ran Shi; Xiao Li Zhang

doi:10.4028/www.scientific.net/AMM.320.522

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 320Synthesis and Cytotoxic Activity of Salicyloyl...

Synthesis and Cytotoxic Activity of Salicyloyl Hydrazone Derivatives

Abstract:

Three salicyloyl hydrazone derivatives (compounds 1-3) were prepared by reacting salicyloyl hydrazine with substituted formaldehydes. Their structures were characterized by melting point, 1H-NMR, ESI-MS and elemental analyses. The cytotoxic activity of compounds 1-3 was evaluated in vitro against Hela cells (human cervical cancer cells). The results revealed that all the compounds showed cytotoxic activity, with IC₅₀ values lower than 15 μM.

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Periodical:

Applied Mechanics and Materials (Volume 320)

Pages:

522-525

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https://doi.org/10.4028/www.scientific.net/AMM.320.522

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Online since:

May 2013

Authors:

Xiao Yang Qiu, An Ran Shi, Xiao Li Zhang

Keywords:

Cytotoxic Activity, Salicyloyl Hydrazone Derivatives, Structureactivity Relationships

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