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A Review on Gene Delivery System of Layered Double Hydroxide

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Abstract:

This paper aims to provide a concise review on the study of a gene delivery system with layered double hydroxides (LDH) as carrier. The issues, such as preparation and cytobiology effect of LDH-DNA hybrids, and the release mechanism of DNA from LDH-DNA complex, were discussed in detail. For achieving a ideal cell transfection efficiency, it would be prospective to improve both the intercalation effect of giant DNA, such as plasmid DNA and long chain DNA fragments, and the gene transfection technique of small DNA fragment.

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Periodical:

Applied Mechanics and Materials (Volume 320)

Pages:

533-539

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.320.533

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Online since:

May 2013

Authors:

Li E Dong, Guo Jing Gou, Jie Huang, Yue Sun, Bing Xue

Keywords:

Gene Transfer, Layered Double Hydroxides (LDHs), LDH-DNA Complex System

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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