Study on Cytotoxicity of “Dextran-Magnetic Layered Double Hydroxide–Fluorouracil” Targeted Liposomes In Vitro

Jie Huang; Bin Xue; Guo Jing Gou

doi:10.4028/www.scientific.net/AMM.320.526

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 320Study on Cytotoxicity of “Dextran-Magnetic Layered...

Study on Cytotoxicity of “Dextran-Magnetic Layered Double Hydroxide–Fluorouracil” Targeted Liposomes In Vitro

Abstract:

This paper studied the cytotoxicity of the dextran-magnetic layered double hydroxide-fluorouracil targeted liposomes ( DET-MLDH-FU liposomes, DMFL ) by MTT method against human ovarian adenocarcinoma cancer cells ( SKOV3 ) in vitro. The results shown that the cellular inhibition rate at 24 h increased with the increasing of the fluorouracil concentration in DMFL, DET-MLDH-FU ( DMF ), fluorouracil-loaded liposomes ( FUL ) and free fluorouracil ( FU ). The order of inhibition rate was DMFL, DMF, FUL and FU at same concentration and intervention time. The IC₅₀ values of DMFL, DMF, FUL and FU were 14.39, 25.47, 34.39, 48.71 ( μgmL^-1 ), respectively. The results of cytotoxicity experiment proved that the DMFL was superior than other preparations of fluorouracil.

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Periodical:

Applied Mechanics and Materials (Volume 320)

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526-528

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.320.526

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Online since:

May 2013

Authors:

Jie Huang, Bin Xue, Guo Jing Gou

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“Dextran-Magnetic Layered Double Hydroxide-Fluorouracil” Targeted Liposomes, Cytotoxicity, Inhibition Rate

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References

[1] S. Tsujimoto, K. Fujimoto, E. Okajima, S. Ozono, E. Okajima and Y. Hirao: International Journal of Clinical Oncology, Vol. 13 (2008) No.2, p.138.

Google Scholar

[2] Q. Tong, L. Hang, W.Y. Chen, H.X. Shu, X.G. Lu, X.M. Wang and B.Guo: Journal of Nanoscience and Nanotechnology, Vol. 11 (2011) No.4, p.3651.

Google Scholar

[3] M.J. Kim, D.H. Jang, Y.I. Lee, H.S. Jung, H.J. Lee and Y.H. Choa: Journal of Nanoscience and Nanotechnology, Vol. 11 (2011) No.1, p.889.

Google Scholar

[4] P. Vincent, W. Claire, M. Véronique, M. Christine, G. Florence, M.R. Jack and L. Sylviane: Advanced Functional Materials, Vol. 21 (2011) No.1, p.83.

Google Scholar

[5] G.J. Gou, F.J. Bao, Y.X. Jiang: China. Patent 101607091A, (2009). (In Chinese).

Google Scholar

[6] G.J. Gou, Z.Y. Wang, Y.H. Liu, B. Xue, J. Huang and Y. Sun: Acta Chimica Sinica, Vol. 70 (2012) No.2, p.161. (In Chinese).

Google Scholar

[7] G.J. Gou, Y.H. Liu, Y. Sun, J. Huang, B. Xue, L.E. Dong: Acta Pharmaceutica Sinica, Vol. 46 (2011) No.11, p.1390. (In Chinese).

Google Scholar

[8] R.Z. Liu, L. Gan and X.L. Yang: Journal Of Bioscience And Bioengineering, Vol. 111 (2011) No.1, p.98.

Google Scholar

[9] A.A. Kuznetsov, V.I. Filippov, R.N. Alyautdin, N.L. Torshina and O.A. Kuznetsov: Journal of Magnetism and Magnetic Materials, Vol. 225 (2001) No.1, p.95.

DOI: 10.1016/s0304-8853(00)01235-x

Google Scholar