Compressive Strength of Porous Bone Cement/Polylactic Acid Composite Bone Scaffolds

Abstract:

Calcium phosphate bone cement (CPC), a bioceramic, is commonly used in artificial bone scaffold for impaired bones. In this study, CPC is mixed with polylactide (PLA) fibers and porogenic agent to form CPC/PLA composite bone scaffold. The compressive strength of the resulting bone scaffolds is evaluated and the fractured cross-section is observed by a scanning electron microscope (SEM), thereby determining the influence of fiber length. The experimental results show that the shorter the fiber is, the greater the compressive strength is.

• Periodical: Applied Mechanics and Materials (Volumes 365-366)
• Pages: 1062-1065
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.365-366.1062
• Online since: August 2013
• Authors: Ching Wen Lou, Wen Cheng Chen, Chao Tsang Lu, Cheng Chun Huang, Jia Horng Lin
• Keywords: Calcium Phosphate Bone Cement (CPC), Composite Bone Scaffold, Compressive Strength, Polylactide (PLA)

References

[1] M. Peter, P. T. S. Kumar, N. S. B., Shanti V. Nair, H. Tamura, R. Jayakumar, Development of novel α-chitin/nanobioactive glass ceramic composite scaffolds for tissue engineering applications, Carbohydr. Polym. 78 (2009) 926-931.

DOI: 10.1016/j.carbpol.2009.07.016

[2] J.H. Lin, C.H. Chang, Y.S. Chen, G.T. Lin, Formation of bone-like apatite on titanium filament by a simulated body fluid inducing process, Surf. Coat. Tech. 200 (2006) 3665 – 3669.

DOI: 10.1016/j.surfcoat.2005.04.010

[3] R. Jayakumara, R. Ramachandrana, P.T. Sudheesh Kumara, V.V. Divyarania, S. Srinivasana , K. P. Chennazhia, H. Tamurab, S.V. Naira, Fabrication of chitin–chitosan/nano ZrO2 composite scaffolds for tissue engineering applications, Int. J. Biol. MacromoL. 49 (2011).

[4] L.L. Hench, T.G. Lee, W.C. Allen, G. Piotrowski, An investigation of a prosthetic Material, U.S. Army, Med. Res. and Develop Command, Contract No. OA 10-70-C-001, 1970-(1975).

[5] A.P. Gupta, V. Kumar, New emerging trends in synthetic biodegradable polymers – Polylactide: A critique, Eur. Polym. J. 43 (2007) 4053-4074.

DOI: 10.1016/j.eurpolymj.2007.06.045

[6] J. F Bridges, M. Critchlow, M. P. Irving, S. C Purkiss, D. C Taylor, J. B Lloyd, Radiolabeling, stability, and body distribution in rats, of low molecular weight polylactide homopolymer and polylactide–polyethyleneglycol copolymer, Biomaterials. 21 (2000).

DOI: 10.1016/s0142-9612(99)00172-6

[7] K. Madhavan Nampoothiri, Nimisha Rajendran Nair, Rojan Pappy John, An overview of the recent developments in polylactide (PLA) research, Thermochimica. Acta. 527 (2012) 1-7.

[8] Y. Wu, Yongli Zheng, W. Yang, C.C. Wang, J.H. Hu, S. k. Fu, Synthesis and characterization of a novel amphiphilic chitosan–polylactide graft copolymer, Carbohydr. Polym. 50 (2005) 165-171.

DOI: 10.1016/j.carbpol.2004.09.006

[9] J.D. Badía, L. Santonja-Blasco, R. Moriana, A. Ribes-Greus, Thermal analysis applied to the characterization of degradation in soil of polylactide: II. On the thermal stability and thermal decomposition kinetics Original Research, Polym. Degrad. Stabil. 95 (2010).

DOI: 10.1016/j.polymdegradstab.2010.06.002