Nanostructured Surface Effect of Electrode on Doxorubicin Determination

Abstract:

In this study, we compared two types of nanostructured electrodes with gold nanocolumns and flat gold electrodes by measurements with doxorubicin. Nanostructured electrodes were fabricated by electrochemical anodic oxidation followed by deposition of gold to the porous alumina. Flat gold electrodes were fabricated by physical evaporation of gold layer to the silicon substrate. All electrodes were characterized by electrochemical impedance spectroscopy and then the electrochemical determination of doxorubicin was studied by differential pulse voltammetry. The impedance spectroscopy measurements proved a bigger electroactive area for nanostructured electrodes. The gold nanocolumns have been found as an important factor in increasing of electrodes active area. This fact is very important for sensors sensitivity. Fabricated electrodes were successfully used for determination of doxorubicin.

• Periodical: Applied Mechanics and Materials (Volumes 490-491)
• Pages: 262-266
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.490-491.262
• Online since: January 2014
• Authors: Hana Kynclová*, Jakub Přibyl, Radim Hrdý, Jana Drbohlavová, Jan Prášek, Jaromír Hubálek
• Keywords: Differential Pulse Voltammetry, Doxorubicin, Electrochemical Impedance Spectroscopy (EIS), Flat Gold Electrode, Gold Nanocolumns, Nanostructured Electrode, Titanium Dioxide

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