3D Texture Analysis of Corpus Caliosum Based on MR Images Inpatients with Alzheimer’s Disease and Mild Cognitive Impairment

Abstract:

This study investigated three-dimensional (3D) texture as a possible diagnostic marker of Alzheimers disease (AD). Methods: T1-weighted MRI of 18 AD patients, 18 Mild Cognitive Impairment (MCI) patients and 18 normal controls (NC) were selected.3D Texture parameters of the corpus callosum,including contrast, inverse difference moment , entropy, short run emphasis, long run emphasis, grey level nonuniformity, run length nonuniformity and fraction were extracted from the gray level co-occurrence matrix and run length matrix. Finally statistic significance was tested among three groups, and the correlations between parameters and Mini-Mental State Examination (MMSE) scores were calculated. Results: The results showed that the 3D texture features had significant differences (p<0.05) among three groups except grey level nonuniformity and run length nonuniformity that the difference was not significant (p>0.05) between MCI and NC or AD and MCI , and they were correlated with MMSE scores.Conclusions: 3D texture analysis can reflect the pathological changes of corpus callosum in patients with AD and MCI, and it may be helpful to AD early diagnosis.

• Periodical: Applied Mechanics and Materials (Volume 533)
• Pages: 415-420
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.533.415
• Online since: February 2014
• Authors: Wei Fang Liu*, Xu Wang, Hong Xia
• Keywords: 3D Texture Features, Alzheimer Disease, Corpus Callosum, Mild Cognitive Impairment, MRI

References

[1] Petrella JR, Coleman RE, Doraiswamy PM. Neuroimaging and early diagnosis of Alzheimer disease: a look to the future. Radiology, 2003, 226(2): 315-336.

DOI: 10.1148/radiol.2262011600

[2] Brookmeyer R, Gray S, Kawas C, et al. Projection of Alzheimer's disease in the United States and the public health impact of delaying disease onset. American Journal of Public Health, 1998, 88(9): 1337-1342.

DOI: 10.2105/ajph.88.9.1337

[3] Alzheimer's Association (2010) Alzheimer's disease facts and figures. Includes a Special Report on Race, Ethnicity and Alzheimer's Disease. (2010).

[4] Grundman M, Petersen RC, Ferris SH, et al. Mild Cognitive Impairment Can Be Distinguished From Alzheimer Disease and Normal Aging for Clinical Trials . Arch Neurol, 2004, 61(1): 59-66.

DOI: 10.1001/archneur.61.1.59

[5] M. Muskulus, AEH. Scheenstra et al. Prospects for early detection of Alzheimer's disease from serial MR images in transgenic mice. Current Alzheimer Research, 2009, 6(6): 503-518.

DOI: 10.2174/156720509790147089

[6] Kovalev VA, Kruggel F, Gertz HJ, and Yves von Cramon, D. Three-dimensional texture analysis of MRI brain datasets. IEEE Transactions on Medical Imaging, 2001, 20(5): 424-433.

DOI: 10.1109/42.925295

[7] Kumar, S. V. B., Mullick, R., and Patil, U. Textural content in 3T MR: An image-based marker for Alzheimer's disease. Proc. of SPIE Medical Imaging, (2005).

DOI: 10.1117/12.596086

[8] Xia Hong, Wang Xu, Tong Longzheng and Liu Weifang. 2D and 3D Texture Features of Corpus Caliosum in Patients with Alzheimer Disease based on MR Images: a Comparative Study. Journal of Beihua University(Natural Science), 2013, 14(5): 553-556.

[9] Szczypinski PM, Strzelecki M, Materka A and Klepaczko A. MaZda-A software package for image texture analysis. Computer Methods and Programs in Biomedicine, 2009, 94: 66-76.

DOI: 10.1016/j.cmpb.2008.08.005

[10] G. Castellano, L. Bonilha, L.M. Li and F. Cendes. Texture analysis of medical images. Clinical Radiology, 2004, 59(12): 1061-1069.

DOI: 10.1016/j.crad.2004.07.008

[11] DH Salat DN, GrevedL Pacheco, et a1．Regional white matter volume differences in nondemented aging and Alzheimer's disease．Neurolmage, 2009, 44: 1247-1258.

DOI: 10.1016/j.neuroimage.2008.10.030

[12] M.S. de Oliveira, M.L.F. Balthazar, A. D'Abreu, et al. MR Imaging Texture Analysis of the Corpus Callosum and Thalamus in Amnestic Mild Cognitive Impairment and Mild Alzheimer Disease. AJNR, 2011, 32(1): 60-66.

DOI: 10.3174/ajnr.a2232

[13] HU Ling-jing, LI Xin, TONG Long-zheng, et al. 3D Texture Analysis of Hippocampus Based on MR Images in Patients With Alzheimer Disease and Mild Cognitive Impairment. Journal of Beinjing University of Technology, 2012, 38(6): 942-948.

DOI: 10.1109/bmei.2010.5639520

[14] Jing Zhang , Chunshui Yu, Guilian Jiang , Weifang Liu and Longzheng Tong. 3D texture analysis on MRI images of Alzheimer's disease. Brain Imaging and Behavior, 2012, 6: 61–69.

DOI: 10.1007/s11682-011-9142-3

[15] Teipel S J, Bayer W, Alexander G E, et al. Progression of corpus callosum atrophy in Alzheimer disease. Archives of Neurology, 2002, 59(2): 243.

DOI: 10.1001/archneur.59.2.243