Research on the Chemical Materials of Inosine Di- and Triphosphate

Cha Ma; Qing Kun Yang; Shan Shan Gong; Qi Sun

doi:10.4028/www.scientific.net/AMM.540.343

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 540Research on the Chemical Materials of Inosine Di-...

Research on the Chemical Materials of Inosine Di- and Triphosphate

Abstract:

Inosine 5′-triphosphate (ITP) and 5′-diphosphates (IDP) were efficiently synthesized. Phosphitylation, acid-catalyzed hydrolysis, and oxidative coupling with piperidine afforded inosine phosphoropiperidate benzyl ester intermediate in good yield. Inosine polyphosphates were obtained by coupling the deprotected phosphoropiperidate with 4,5-dicyanoimidazole (DCI) as the activator.

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Periodical:

Applied Mechanics and Materials (Volume 540)

Pages:

343-346

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.540.343

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Online since:

April 2014

Authors:

Cha Ma, Qing Kun Yang, Shan Shan Gong, Qi Sun*

Keywords:

4,5-Dicyanoimidazole, Diphosphates, Inosine, Phosphoropiperidate, Triphosphate

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