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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 540Research on the Chemical Material of...

Research on the Chemical Material of P¹-Stavudine-P²-Acyclovir Diphosphate

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Abstract:

A novel and efficient method for the preparation of P¹-stavudine-P²-acyclovir diphosphate has been developed. Acyclovir phosphoropiperidate was prepared from a redox condensation with 2,2′-dithiodianiline/PPh₃. Then, the coupling of phosphoropiperidate with d4T phosphate in the presence of 4,5-dicyanoimidazole as the activator afforded the desired asymmetrical dinucleoside diphosphate in high yield.

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Advanced Research on Mechanics, Manufacturing Engineering and Applied Technology II

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Periodical:

Applied Mechanics and Materials (Volume 540)

Pages:

339-342

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.540.339

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Online since:

April 2014

Authors:

Shan Shan Gong, Qi Sun*

Keywords:

Activation, Acyclovir, Antiviral, Dinucleoside Diphosphate, Stavudine

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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