Effect of Stenosis Eccentricity in a Model of Bifurcated Coronary Artery

Abstract:

This study was to implement fluid structure interaction (FSI) method in order toinvestigate the effect of stenosis eccentricity on the recirculation flow, pressure drop and wall shearstress (WSS) in an atherosclerotic model of a left coronary artery with left anterior descending(LAD) and left circumflex (LCX) branches. The linear regression analysis results showed a positivecorrelation between WSS and stenosis eccentricity. The results also showed that the stenosiseccentricity plays a prominent role in determining the pressure drop and recirculation area, whilehaving relatively unnoticeable effects on WSS.

• Periodical: Applied Mechanics and Materials (Volume 553)
• Pages: 332-337
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.553.332
• Online since: May 2014
• Authors: Babak Fakhim, Ashkan Javadzadegan, Rahman T. Nakkas, Masud Behnia
• Keywords: Eccentricity, FSI, Left Coronary Artery, Wall Shear Stress (WSS)

References

[1] F.H. Martini, J.L. Nath, et al., Fundamentals of Anatomy and Physiology, eighth ed., Pearson Education, (2009).

[2] L.J. Shaw, D.S. Berman, et al., Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: results from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial nuclear substudy, Circulation 117 (2008).

DOI: 10.1161/circulationaha.108.779082

[3] M.M. Li F, McDermott, D. Li, et al., The association of lesion eccentricity with plaque morphology and components in the superficial femoral artery: a high-spatial-resolution, multi-contrast weighted CMR study, J Cardiovasc Magn Reson. 12 (2010).

DOI: 10.1186/1532-429x-12-37

[4] M. Yamagishi, M. Terashima, et al., Morphology of vulnerable coronary plaque: insights from follow-up of patients examined by intravascular ultrasound before an acute coronary syndrome, J Am Coll Cardiol. 35 (2000) 106-111.

DOI: 10.1016/s0735-1097(99)00533-1

[5] J. Ohayon, G. Finet, et al., A three-dimensional finite element analysis of stress distribution in a coronary atherosclerotic plaque: In-vivo prediction of plaque rupture location, Biomechanics Applied to Computer Assisted Surgery (2005) 225-241.

DOI: 10.1097/00019501-200112000-00009

[6] S. Bernad, E. Bernad, R. Susan-Resiga, T. Barbat, Computational Hemodynamics in Three Dimensional Stenosed Right Coronary artery, University of Timisoara, (2008) 81-86.

[7] E. Shaik, and K.A. Hoffman, Numerical simulations of blood flow in arteries using fluid structure interactions, PhD dissertation, Graduate School of Witchita State University, (2007).