Natural-Synthetic Polymer Blend Composite Scaffold for Bone Tissue Engineering: Study of In Vitro Degradation and Protein Adsorption

Naznin Sultana

doi:10.4028/www.scientific.net/AMM.554.42

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 554Natural-Synthetic Polymer Blend Composite Scaffold...

Natural-Synthetic Polymer Blend Composite Scaffold for Bone Tissue Engineering: Study of In Vitro Degradation and Protein Adsorption

Abstract:

In the current study, poly (hydroxy butyrate-co-hydroxy-valerate) (PHBV) was blended with a synthetic polymer poly (L-lactic acid) (PLLA), to control the degradation rate and process of composite scaffolds, as PLLA has a much higher degradation rate than PHBV. PHBV/PLLA blends were used as polymer matrices for composite scaffolds. Emulsion freezing / freeze-drying technique was used to fabricate composite scaffolds based on these blends and containing nanosized hydroxyapatite (nHA). In vitro degradation tests of composite scaffolds were conducted by immersing samples in phosphate buffered saline (PBS) for various periods of time. It was found that the composition of polymer blends affected water uptake of scaffolds. Composite scaffolds exhibited enhanced adsorption of bovine serum albumin (BSA), a model protein.

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Periodical:

Applied Mechanics and Materials (Volume 554)

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42-46

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.554.42

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Online since:

June 2014

Authors:

Naznin Sultana

Keywords:

Adsorption, Composite, Degradation, Polymer Blend, Proten, Tissue Engineering

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References

[1] S.J. Hollister, Porous scaffold design for tissue engineering, Nature Mater. 4(2005)518-524.

Google Scholar

[2] P.A. Holmes, Developments in Crystalline polymers-2, in D.C. Basset, (Eds. ), Elsevier, London, (1987).

Google Scholar

[3] S. Iannace, L. Ambrosio, S.J. Huang, L. Nicolais, Poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate)/poly-L-Lactide blends: thermal and mechanical properties, J. Applied Polymer Science. 54(1994) 1525.

DOI: 10.1002/app.1994.070541017

Google Scholar

[4] B.M. P. Ferreira, C.A.C. Zavaglia, E.A. R Duek, Films of poly (L-lactic acid)/ poly (hydroxybutyrate-co-valerate) blends: degradation, Mater Res. 4 (2001) 34.

DOI: 10.1590/s1516-14392001000100008

Google Scholar

[5] N. Sultana and T.H. Khan, Polycaprolactone Scaffolds and Hydroxyapatite/Polycaprolactone Composite Scaffolds for Bone Tissue Engineering, J Bionanoscience. 5( 2013) 169-173.

DOI: 10.1166/jbns.2013.1112

Google Scholar

[6] N. Sultana and T.H. Khan, Water Absorption and Diffusion Characteristics of Nanohydroxyapatite (nHA) and Poly(hydroxybutyrate-co-hydroxyvalerate-) Based Composite Tissue Engineering Scaffolds and Nonporous Thin Films, J Nanomater. 2013 (2013).

DOI: 10.1155/2013/479109

Google Scholar

[7] N. Sultana and M. Wang, PHBV/PLLA-based composite scaffolds fabricated using an emulsion freezing/freeze-drying technique for bone tissue engineering: surface modification and in vitro biological evaluation, Biofabrication. 4 (1) (2012), 015003.

DOI: 10.1088/1758-5082/4/1/015003

Google Scholar

[8] G. Wei and P.X. Ma, Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering, Biomaterials. 25 (2004), 4749-4757.

DOI: 10.1016/j.biomaterials.2003.12.005

Google Scholar

[9] W.Y. Zhou, M. Wang, W.L. Cheung, B.C. Gao, D.C. Jia, Synthsis of carbonated hydroxyapatite nanospheres through nanoemulsion, J. Mater Sci: Mater Med. 18 (2007) 103-110.

DOI: 10.1007/s10856-007-3156-9

Google Scholar