Application of Isomap Method in Prediction of Protein Quaternary Structure
A new method for the prediction of protein quaternary structure is constructed based on Isomap (Isometric feature mapping) algorithm, which is a manifold learning-based data mining method. DC (Dipeptide Composition) is used as sequence encoding scheme for the construction of decision system. A DR (Dimensionality Reduction) algorithm, the so-called Isomap is introduced to reduce the decision system, which can be used to classify new objects. The results thus obtained in predicting the quaternary structure of proteins are quite encouraging.
T. Wang et al., "Application of Isomap Method in Prediction of Protein Quaternary Structure", Applied Mechanics and Materials, Vols. 58-60, pp. 840-842, 2011