Thermal Lens Microscopy: Characterization and Optimization

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Abstract:

Thermal lens microscopy (TLM) is a highly sensitive photothermal technique, and has found various applications in chemical analysis, especially when it is combined with lab-on-a-chip chemistry. In this paper, we analyze a couple of key characteristics of TLM, and give suggestions for optimization of the system for higher detection sensitivity, lower noise, lower irradiation density and/or better temporal and spatial resolutions. This will advance the development of TLM instrument for different chemical and biochemical analyses.

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317-321

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August 2014

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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[1] E. Livak-Dahl, I. Sinn, M. Burns, Microfluidic chemical analysis systems, Annu. Rev. Chem. Biomol. Eng. 2 (2011) 325-353.

DOI: 10.1146/annurev-chembioeng-061010-114215

Google Scholar

[2] W. -C. Tian, E. Finhout, Microfluidics for Biological Applications, Springer Science+Business Media, New York, (2008).

Google Scholar

[3] P. I. Okabare, S. A. Soper, High throughput single molecule detection for monitoring biochemical reactions, Analyst 134 (2009) 97-106.

DOI: 10.1039/b816383a

Google Scholar

[4] M. Harada, K. Iwamoto, T. Kitamori, T. Sawada, Photothermal microscopy with excitation and probe beams coaxial under the microscope and its application to microparticle analysis, Anal. Chem. 65 (1993) 2938-2940.

DOI: 10.1021/ac00068a037

Google Scholar

[5] T. Kitamori, M. Tokeshi, A. Hibara, K. Sato, Thermal lens microscopy and microchip chemistry, Anal. Chem. 76 (2004) 52A-60A.

DOI: 10.1021/ac041508d

Google Scholar

[6] Information on http: /www. i-mt. co. jp.

Google Scholar

[7] M. Liu, M. Franko, Progress in thermal lens spectrometry and its applications in microscale analytical devices, Crit. Rev. Anal. Chem. 44 (2014) 328-353.

DOI: 10.1080/10408347.2013.869171

Google Scholar

[8] E. Tamaki, A. Hibara, M. Tokeshi, T. Kitamori, Tunable thermal lens spectrometry utilizing microchannel-assisted thermal lens spectrometry, Lab Chip 5 (2005) 129-131.

DOI: 10.1039/b413218a

Google Scholar

[9] M. Liu, M. Franko, An incoherent light source excited thermal lens microscope, Appl. Phys. Lett. 100 (2012) 121110-1~4.

DOI: 10.1063/1.3696049

Google Scholar

[10] M. Liu, M. Franko, Thermal lens spectrometry under excitation of a divergent pump beam, Appl. Phys. B 115 (2014) 269-277.

DOI: 10.1007/s00340-013-5601-4

Google Scholar