Water management is one of the most critical and widely studied topics in what concerns proton exchange membrane fuel cell (PEMFC). Traditional macroscopic models of two-phase transport in PEMFCs generally assume “homogeneous” medium and are based on the concept of volumetric averaging, thus lumping all the detailed information of the structural morphology inside a PEMFC. Mesoscopic models have the potential to reveal the underlying pore-scale mechanism of two-phase transport in PEMFCs. This paper aims to review the sate-of-the-art and perspective of the PEMFC mesoscopic two-phase transport models, mainly the pore network (PN) model and the Lattice Boltzmann (LB) model. We will talk about what we are planning to do using the LB model as well.