The purpose of this study was to evaluate the geological and anthropogenic aspects of As pollution in groundwater of Northern Suburb Groundwater Source Field in Zhengzhou, China. Based on the groundwater samples of 78 wells in the groundwater source field of some northern city in China, distribution and influencing factors of arsenic were analyzed. The results show that: in the horizontal direction, the arsenic concentration outside beach is higher than that inside; the arsenic concentration presents the regional and continual distribution in the east area and west area, respectively. The arsenic concentration was reduced along with the increase of depth in the vertical direction. Arsenic concentration has significantly correlations with pH, Fe, Mn, SO42- and the water level of Yellow River, respectively (r = 0.5011, 0.7302, 0.6231, -0.5222 and -0.7671), which are the primary influencing factors on the mobilization and transform of arsenic in the groundwater.