Determination of Competitive Adsorption Isotherm of the Etodolac Enantiomers Using Inverse Method

Abstract:

The competitive adsorption isotherm of etodolac enantiomers on a cellulose carbamates-based chiral stationary phase (Chiralcel OD) at 25°C was determined in this study by the inverse method (IM). An equilibrium dispersive (ED) model combined with bi-Langmuir adsorption model was used in predicting the elution profiles. The adsorption isotherm model with 5 parameters was determined by fitting the two overloaded band profiles. The non-dominated sorting genetic algorithm (NSGA-II) and Levenberg-Marquardt algorithm (LMA) were crucial tools and utilities in this process. Suitable model parameters have been obtained and the experimental results were in good agreement with the model predictions.

• Periodical: Applied Mechanics and Materials (Volumes 716-717)
• Pages: 79-83
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.716-717.79
• Online since: December 2014
• Authors: Su Qi, Li Hui, Wei Fang Yu*
• Keywords: Competitive Adsorption Isotherm, Etodolac Enantiomers, Inverse Method

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