Alginate Scaffolds with Modified Micro Pores for Tissue Engineering Applications

Bon Kang Gu; Sang Jun Park; Min Sup Kim; Chun Ho Kim

doi:10.4028/www.scientific.net/AMM.749.457

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 749Alginate Scaffolds with Modified Micro Pores for...

Alginate Scaffolds with Modified Micro Pores for Tissue Engineering Applications

Abstract:

In this study, we developed the porous alginate (AL) scaffolds with modified pores size and distributions to actively control tissue regeneration. An addition of 5 and 10% (v/v) butanol to AL solution was effective to control pores structures of AL scaffolds. Especially, increased amount of butanol induced that proportion of smaller pores (size of around 5~10 μm) on AL scaffolds increased. Using swelling kinetics analysis, we confirmed that micro pore modified AL scaffolds show faster swelling rate than pristine scaffolds. During in vitro study, the enhanced viability and proliferation of human dermal fibroblasts (HDFs) were observed by the pore size and distribution from micro pore modified AL scaffolds. However, AL scaffolds added 10 % butanol with excessive proportion of smaller pores induced the decreased viability of HDFs for 7 days. From our results, AL scaffolds with modified pores structures represent a potential implants to control biological in vitro and in vivo functions in a variety of tissue engineering.

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Periodical:

Applied Mechanics and Materials (Volume 749)

Pages:

457-460

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.749.457

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Online since:

April 2015

Authors:

Bon Kang Gu, Sang Jun Park, Min Sup Kim, Chun Ho Kim*

Keywords:

Alginate, Modified Micropores, Scaffold, Tissue Engineering

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