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Inhibition of Herpes Simplex Virus Type 2 In Vitro by Durian (Durio zibethinus Murray) Seed Coat Crude Extracts

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Abstract:

The aim of this study was to determine Herpes simplex virus type 2 (HSV-2G) inhibition by durian seed coat crude extracts. Dried native durian seed coat from Lab-Lae District, Uttaradit Province was extracted with solvents; distilled water and ethanol. Subsequently, two durian seed coat crude extracts were investigated their cytotoxicity on Vero cells and determined HSV-2G inhibition by plaque reduction assay. The results displayed that 50%cytotoxicity dose (CD50) of aqueous and ethanolic extracts of durian seed coat were 224.40 and 112.47 μg/ml, respectively. Moreover, the aqueous and ethanolic extracts of durian seed coat at a concentration of 100 μg/ml could inhibit HSV-2G by 36.34 ± 1.47 and 61.56 ± 5.30%, respectively. This study displayed the one of advantages of native seed durian in Uttaradit.

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Periodical:

Applied Mechanics and Materials (Volume 855)

Pages:

60-64

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.855.60

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Online since:

October 2016

Authors:

Jiraporn Nikomtat*, Pattachai Pinnak, Kodchakorn Lapmak, Pathompong Tammalungka, Thitiphorn Thiankhanithikun1 Thiankhanithikun, Yingmanee Tragoolpua

Keywords:

Durian, Durian Extract, Herpes Simplex Virus, Plant Extract, Seed Coat

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Creative Commons CC BY 4.0

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