Development of a Hydroxypropyl-β-Cyclodextrin Complex for Improving Water Solubility and Reducing Skin Sensitivity of Salicylic Acid

Abstract:

The present work reports on complexation of hydroxypropyl-β-cyclodextrin (HP-β-CD) with salicylic acid (SA) by vacuum evaporation and inclusion behavior confirmed by FT-IR, OM and SEM. Complex stoichiometry, release mechanism and skin sensitivity were evaluated. The results showed that SA could be encapsulated into cyclodextrin at the ratio of 1:1. Negative values of Gibbs free energy, enthalpy and entropy changes indicated a feasible, spontaneous and exothermic process. Release studies evidenced a burst release in first 2 h, followed by a sustained release and the release rate was temperature-dependent. Furthermore, an improved water solubility and significant reduced irritation effect of SA could be obtained by HP-β-CD.

• Periodical: Advanced Materials Research (Volumes 1004-1005)
• Pages: 919-923
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1004-1005.919
• Online since: August 2014
• Authors: Yi Qing Huang, Qiang Xia*
• Keywords: Hydroxypropyl-β-Cyclodextrin, Salicylic Acid, Skin Sensitivity, Water Solubility

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