Synthesis and Characterization of Novel Degradable and Temperature/Ionic-Strength Responsive Polyurethane Microsphere

Ke Wei Yu; Yang Quan Deng; Shu Wen Yu; Wei Min Zhang

doi:10.4028/www.scientific.net/AMR.1033-1034.1077

Paper Titles

Preparation of Cu/Co/Fe Mixed Oxides and their Catalytic Behavior on HC-SCR DeNOx
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Research on the Preparation and Antibacterial Property of Nanometer-Magnesium Oxide Powder
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Self-Assembled Core-Shell Fe₃O₄@SiO₂Nanoparticles with High Magnetic Sensitivity from Electrospun Fibers
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Study on Heavy Metal Ion Adsorption of PAN-Amidoxime Nanofiber Nonwoven Material
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Synthesis and Characterization of Novel Degradable and Temperature/Ionic-Strength Responsive Polyurethane Microsphere
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Nano-Chromium Trioxide Preparation from Chromium-Containing Waste Liquid Accompanying 16-Dehydropregnenolone Acetate
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Preparation and Characterization of Carbon Nanofibers from the High Temperature Controllable Flame
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Fabrication of NF-PLLA Scaffolds by Gel Extraction Phase Separation
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Synthesis of Oriented ZnO Nanofibers Using Electrospun Method on Si (100) Substrate
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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 1033-1034Synthesis and Characterization of Novel Degradable...

Synthesis and Characterization of Novel Degradable and Temperature/Ionic-Strength Responsive Polyurethane Microsphere

Abstract:

The present study describes degradable and temperature/ionic-strength responsive polyurethane (PU) microspheres fabricated using toluene diisocyanate, polycaprolactone, polyethylene glycol, 2, 2-hydroxymethyl-2-propionic acid and triethylamine for drug delivery.^[1]We studied the properties of Temperature-sensitive, Ionic strength effects on SR, Swelling-deswelling reversibility, In vitro degradation, the result showed that: when the increase in temperature between 20°C and 50°C, as well as the ionic strength at certain temperature tended to decrease SR. The swelling kinetics was also investigated showing the presence of good ability to change reversibly at different temperature. The degradable studies using phosphate buffer solvent revealing polymeric matrix easily be tuned by varying polycaprolactam (PCL) composition, thus matching specific requirements.