Preparation of pH-Sensitive Aqueous P(MAA-co-EA) Copolymers and Application in Omeprazole Capsules

Abstract:

A series of different molecular weight aqueous enteric P(MAA-co-EA) copolymer coating material were prepared by varying the amount of chain transfer agent in the process of emulsion polymerization. Using fluidized bed technology, omeprazole enteric-coated capsules were obtained via omeprazole pellets containing the isolation layer were coated by P(MAA-co-EA) copolymers emulsion, following vitro enteric test was carried out . The results showed that when the dosage of the chain transfer agent was 0.789% of the total monomer mass, the obtained P(MAA-co-EA) copolymer was used as the coating material of omeprazole capsule, which the resistance to acid was good for 2h and the release rate of the pellet tablets was quick in artificial intestinal liquid, and the test data was consistent with National Standards, and the storage stability was excellent.

• Periodical: Advanced Materials Research (Volumes 1033-1034)
• Pages: 255-258
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1033-1034.255
• Online since: October 2014
• Authors: Xiao Qi Chen, Dan Zheng, Chao Liu, Xiao Lei Zhang, Hai Jun Zhou, Ying Cheng, Yan Tao Li*
• Keywords: Chain Transfer Agent, Molecular Weight, Omeprazole, Release

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