Role of Main Physical Properties in Granule Yield of Andrographis Extract Mixtures in the High Shear Granulation

Abstract:

The purpose of this study was to establish a relationship between the physical properties of powder and its behavior during high shear granulation. Andrographis extract was utilized as a model drug and microcrystalline cellulose (MCC) and soluble starch were selected as excipients. The extract was mixed with different excipient with the ratio 1:0.5, 1:1, 1:2 by weigh, respectively. The granules were prepared by using high shear granulation. The result of HSG was evaluated by monitoring such responses as granule yield, the ratio of Lumps and Fine. The effect of physical properties on granulation behavior was analyzed through stepwise regression. The results showed that angle of repose, moisture content, pore volume, and density were the main factors linked to the granulation. The main physical properties of extract powder were the important factors for high shear granulation, and statistical analysis identified the trends that interpreted in light of physical models of high shear granulation.

• Periodical: Advanced Materials Research (Volumes 1033-1034)
• Pages: 265-270
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1033-1034.265
• Online since: October 2014
• Authors: Zheng Gen Liao, Zhe Li, Liang Shan Ming, Juan Luo, Qie Ying Jiang, Xin Li Liang, Guo Wei Zhao*
• Keywords: Granule, High Shear Granulation, Physical Properties, Powder, Stepwise Regression

References

[1] Z. Z Liao, L. S. Ming and Y. Luo. Chin. Pharm. J. Vol. 49 (2014), p.572.

[2] D. M. Ranjit, C. J James and H. J. Michael. Powder Technol. Vol. 229 (2012), p.126.

[3] L. Shi, Y. Feng, Sun C C. [J]. Powder Technol. Vol. 208 (2011), pp.663-668.

[4] O. Planinšek, A. Trojak, S. Srčič. Int. J. Pharm. Vol. 221 (2001), pp.211-217.

[5] S. M. Iveson, J. D. Litster, K. Hapgood. Powder Technol., Vol. 117 (2001), p.3.

[6] L. X. Liu, J. D. Litster, S. M. Iveson. AIChE J., Vol. 46 (2000), p.529.