Synthesis and Biological Activities of 1,2,4-Triazine Derivatives

Article Preview

Abstract:

To sdudy the synthesis and biological activities of 1,2,4-triazine derivatives, a series of 1,2,4-triazines were prepared from the reaction of 3-mercapto-5-hydroxyl-6-methyl-1,2,4-triazine with alkyl halide.The structures of prepared compounds were confirmed by IR, 1H-NMR and elemental analysis. Biological activities showed the compounds had anti-inflammatory activities.

You might also be interested in these eBooks

Info:

Periodical:

Advanced Materials Research (Volumes 1033-1034)

Pages:

283-286

Citation:

Online since:

October 2014

Authors:

Export:

Price:

Permissions CCC:

Permissions PLS:

Сopyright:

© 2014 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

[1] Jiang Y, Wang Y, Hua J, et al. Chem. Commun., 2010, 46: 4689-4691.

Google Scholar

[2] Michael G B D, Mark R S J F, Andreas G, et al. Polyhedron, 2006, 25: 888-900.

Google Scholar

[3] Teodozja L, Tetrahedron, 2005, 61: 8148-8158.

Google Scholar

[4] Kozhevnikov V N, Kozhevnikov D N, Shabunina O V. Tetrahedron Lett., 2005, 46: 1521-1523.

Google Scholar

[5] Schuster D P. Dovepress., 2010, 3: 253-262.

Google Scholar

[6] Viktor V V, Andrey P A, Daniel R, et al. Chem. Biol., 2009, 13: 272-283.

Google Scholar

[7] Klaman L D, Boss O, Peron O D, et al. Mol. Cell. Biol., 2000, 20(15): 5479-5489.

Google Scholar

[8] Laurent L, Matthew S, Michel L T. Biochimica et Biophysica Acta., 2010, 1804: 613-619.

Google Scholar

[9] George F. Res. Clin. Endocrinol. Metab., 2007, 21(4): 621-640.

Google Scholar

[10] Iwashita A, Maemoto T, Nakada H, et al. Exp. Ther., 2003, 307(3): 961-968.

Google Scholar

[11] Ping Nie, Wenping Zeng, Xiangsheng Duan. [J] Fine chemical intermediates, 2001, 31(3): 18-20. In Chinese.

Google Scholar

[12] Xiaochun He, Lihua Qiu, Jianping Zhou. [J] Orgenic Cheminstry, 2010, 46: 4609-4611 In Chinese.

Google Scholar