Preparation of Compound Danshen Micropowder Tablets and Comparative Study of Pharmacokinetics with Compound Danshen Extraction Tablets

Peng Yi Hu; Qin Zheng; Ying Ying Gong; Guo Song Zhang; Peng Fei Yue; Zhen Feng Wu; Ming Yang

doi:10.4028/www.scientific.net/AMR.1033-1034.315

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 1033-1034Preparation of Compound Danshen Micropowder...

Preparation of Compound Danshen Micropowder Tablets and Comparative Study of Pharmacokinetics with Compound Danshen Extraction Tablets

Abstract:

Compond Danshen micropowder tablets and extraction tablets were firstly prepared respectively. Then the contents of salvianolic acid B, tanshinone IIA, tanshinone I, cryptotanshinone, notoginsenoside R1,ginsenoside Rg1 and ginsenoside Rb1 in these two kinds of tablets were determined by HPLC, and the results showed that the contents in micropowder tablets were more than them in extraction tablets. A pharmacokinetic comparative study of micropowder tablets with extraction tablets by intragastric administration was developed. Pharmacokinetic parameters suggested that micropowder tablets in rats in vivo bioavailability degree (AUC), peak concentration (Cmax) were 2.14, 1.64 times than the extraction tablets, respectively, and the Tmax of micropowder tablets was longer.

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Periodical:

Advanced Materials Research (Volumes 1033-1034)

Pages:

315-319

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1033-1034.315

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Online since:

October 2014

Authors:

Peng Yi Hu, Qin Zheng, Ying Ying Gong, Guo Song Zhang, Peng Fei Yue, Zhen Feng Wu, Ming Yang*

Keywords:

Compound Danshen, Content, Extraction Tablets, Micropowder Tablets, Pharmacokinetic Parameters

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* - Corresponding Author

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