Study on Synthesis of a Series of Amino Functional Cholesterylated Hepatic Targeting Liposome Ligands

Xiao Chun Wu; Li Hai; Yong Wu

doi:10.4028/www.scientific.net/AMR.1033-1034.324

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 1033-1034Study on Synthesis of a Series of Amino Functional...

Study on Synthesis of a Series of Amino Functional Cholesterylated Hepatic Targeting Liposome Ligands

Abstract:

A series of hepatic amino functional cholesterylated hepatic targeting liposome ligands L₁-L₆ were synthesized. Cholesterol as starting material, after esterification with p-toluenesulfonyl chloride to get cholesterol tosylate, then etherification with oligo ethylene ethanol (n=1-3) to get amino functional cholesterylated compounds T₁-T₃, T₁-T₃ were elongated by reaction with protected diethylene glycol and deprotected in acid condition to get T₄-T₆ . L₁-L₆ were mesylated and replaced by azido group, then hydrogenanted by hydrogen to get L₁-L₆.The target compounds affords cholesterylated hepatic targeting liposome ligands.

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Periodical:

Advanced Materials Research (Volumes 1033-1034)

Pages:

324-328

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1033-1034.324

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Online since:

October 2014

Authors:

Xiao Chun Wu*, Li Hai, Yong Wu

Keywords:

Amino Functional Group, Cholesterylated Compounds, Hepatic Targeting, Synthesis

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