A Synthetic Approach for the Preparation of P¹-AZT-5′-P³-d4T-5′-Triphosphate

Abstract:

A novel and efficient method for the preparation of P¹-AZT-5′-P³-d4T-5′-triphosphate has been developed. The title compound was characterized with ¹H, ¹³C, and ³¹P NMR and mass spectrometry. The experimental results indicated that the employment of 4,5-dicyanoimidazole (DCI) as the activator could notably promote the coupling reaction of AZT 5′-phosphoropiperidate and d4T 5′-diphosphate.

• Periodical: Advanced Materials Research (Volume 1046)
• Pages: 100-103
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1046.100
• Online since: October 2014
• Authors: Shan Shan Gong, Qi Sun*
• Keywords: Antiviral, AZT, d4T, Dinucleoside Triphosphate, Nucleoside

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