Evolution Profile for Assessing Drug-Induced Arrhythmia Using Multifunctional Cardiomyocyte-Based Biosensor

Tian Xing Wang; Kai Qi Su; Ning Hu; Ping Wang

doi:10.4028/www.scientific.net/AMR.1058.339

Paper Titles

Influence of Li, Al Substitution for Mn on Crystal Structure and Electrochemical Performance of Li_1+xMn_2-x-yAl_yO₄ Cathode Materials
p.297

Synthesis and Electrochemical Properties of Cathode Material LiNi_0.8Co_0.1Mn_0.1O₂via Li, Mg, Al Dopping
p.302

Impacts of Cr Substitution on Ion Distributions and Electrochemical Performance of LiNi_0.5-xCr_2xMn_1.5-xO₄ Cathode Materials
p.307

Effect of Solid Reaction Temperature on the Cation Mixing and Electrochemical Properties of LiNi_0.4Co_0.2Mn_0.4O₂ Catode Materials in High Energy Li-Ion Batteries
p.312

Surface Coating and Electrochemical Properties of LiNi_0.8Co_0.15Al_0.05O₂ Cathode in Lithium-Ion Cells
p.317

Inhibitive Effect of a New Dental Resin Composite on Enamel Artificial Caries
p.323

Planar Morphology of Silver Leakage at Resin-Dentin Adhesion Interface
p.329

The Effect of Norcantharidin on Proliferation and Invasiveness of SW579 Cell
p.335

Evolution Profile for Assessing Drug-Induced Arrhythmia Using Multifunctional Cardiomyocyte-Based Biosensor
p.339

HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 1058Evolution Profile for Assessing Drug-Induced...

Evolution Profile for Assessing Drug-Induced Arrhythmia Using Multifunctional Cardiomyocyte-Based Biosensor

Abstract:

In vitro rapid cell-based bioassay is one of the effective methods to evaluate cardio-myocyte function by characteristics of beating rate, contractility, and toxicity. In this study, rapid profile assessing drug-induced arrhythmia was studied by treating cardiomyocyte-based biosensor with some drugs, which resulted in compound-specific changes in the cardiomyocyte beating evolution profiles and growth evolution profiles. Also, rapid profile assessment of cardiomyocyte-based biosensor was also determined by several types of compoundsFrom the compound experiment results, cardiomyocyte-based biosensor with real-time cell analysis technology can monitor the cardiomyocyte beating status in a non-invasive way and indicate the potential of drug-induced arrhythmia.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Advanced Materials Research (Volume 1058)

Pages:

339-343

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1058.339

Citation:

Cite this paper

Online since:

November 2014

Authors:

Tian Xing Wang, Kai Qi Su, Ning Hu, Ping Wang

Keywords:

Cardiotoxicity, Drug-Induced Arrhythmia, Multifunctional Cardiomyocyte-Based Biosensor, Profile Assessment

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

References

[1] R.R. Shah, Pharmacogenomics, 7(2006) 889-908.

Google Scholar

[2] C. Lawrence, C. Pollard, T. Hammond, et al., British J. Pharmacology, 154(2008) 1516-1522.

Google Scholar

[3] S. Whitebread, J. Hamon, D. Bojanic, et al., Drug discovery today, 10(2005) 1421-1433.

Google Scholar

[4] M.C. Eisenberg, Y. Kim, R. Li, et al., Proc. National Academy of Sciences, 108(2011) 20078-20083.

Google Scholar

[5] C.R. Keese, J. Wegener, S.R. Walker, et al., Proc. National Academy of Sciences, 101 (2004) 1554.

Google Scholar

[6] N. Ke, X. Wang, X. Xu, Y.A. Abassi, Methods Mol Biol, 740(2011) 33-43.

Google Scholar

[7] B. Xi, N. Yu, X. Wang, X. Xu, Y. Abassi, Biotechnology journal, 3(2008) 484-495.

Google Scholar

[8] I. Giaever, C. Keese, Proceedings of the National Academy of Sciences, 81(1984) 3761.

Google Scholar

[9] M.C. Nowycky, A.P. Fox, R.W. Tsien, Proc. National Academy of Sciences, 82(1985) 2178.

Google Scholar

[10] M.R. Duchen, A. Leyssens, M. Crompton, The Journal of cell biology, 142(1998) 975-988.

Google Scholar

[11] P.K. Singal, N. Iliskovic, New England Journal of Medicine, 339(1998) 900-905.

Google Scholar